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TranscriptomicsExamination of protein expression patterns of closely related Salmonella serovars using 2D GE and MS/MS
The objective of the present investigation was to consider the level of variation in the protein expression patterns of closely related Salmonella serovars, in order to search for protein factors with levels of expression or posttranslational modifications characteristic for each serovar. For the co...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Enteritidis 
2008-02-26 | E-GEOD-8931 | biostudies-arrayexpress
ProteomicsTRIM21 innate immune detection of GBP1-positive Toxoplasma gondii is essential for host survival
Interferon gamma (IFN) is the major pro-inflammatory cytokine conferring resistance to the intracellular vacuolar pathogen Toxoplasma gondii. Autophagy along with immunity-related GTPases (IRGs), guanylate binding proteins (GBPs) and the E3 ubiquitin ligase TNF receptor-associated factor 6 (TRAF6) m...
ORGANISM(S): Mus musculus (Mouse) Toxoplasma gondii ME49 
2018-03-12 | PXD003217 | Pride
Proteomics Toxoplasma gondii Trim21 
ProteomicsIntegrin beta 3 regulates cellular senescence by activating the TGFβ pathway
Cellular senescence is an important in vivo mechanism that prevents the propagation of damaged cells. However, the precise mechanism(s) regulating senescence are not well characterized. Here, we find that ITGB3 (integrin beta 3 or β3) is epigenetically regulated by the Polycomb protein CBX7. β3 expr...
ORGANISM(S): Homo sapiens (Human) 
2017-03-09 | PXD005717 | Pride
Senescence Silac Cbx7 
ProteomicsAnalysis of signaling endosome composition and dynamics using SILAC in embryonic stem cell-derived neurons
Neurons require efficient transport mechanisms such as fast axonal transport to ensure neuronal homeostasis and survival. Neurotrophins and their receptors are conveyed via fast axonal retrograde transport of signaling endosomes to the soma, where they elicit transcriptional responses. Despite the e...
ORGANISM(S): Mus musculus (Mouse) 
2015-12-21 | PXD002111 | Pride
Mass spectrometry Silac Motor neurons Signalling endosomes 
ProteomicsFunctional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulation.
Allosteric regulation is central to the role of the glycolytic enzyme pyruvate kinase M2 (PKM2) in cancer metabolism. Multiple activating and inhibitory allosteric ligands regulate PKM2 activity by controlling the equilibrium between high activity tetramers and low activity dimers and monomers. Howe...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD010334 | Pride
Srm Prm Pkm2 Quantitation Qexactive 
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