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ProteomicsCROP: A Retromer- PROPPIN complex mediating membrane fission in the endo-lysosomal system
Endo-lysosomal compartments exchange proteins by fusing, fissioning, and through endosomal transport carriers. Thereby, they sort many plasma membrane receptors and transporters and control cellular signaling and metabolism. How the membrane fission events are catalyzed is poorly understood. Here, w...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-05-05 | PXD031244 | Pride
Endo-lysosomal system Yeast 
ProteomicsEndo-Lysosomal Proteins and Ubiquitin CSF Concentrations in Alzheimer’s and Parkinson’s Disease
Alzheimer’s (AD) and Parkinson’s disease (PD) are neurodegenerative disorders characterized by an accumulation of protein aggregates in the brain. AD is the most common cause of dementia and presents with impairment of memory and cognition. PD results from the loss of dopaminergic neurons which resu...
ORGANISM(S): Homo Sapiens 
PXD013451 | panorama
ProteomicsRegulatory function of sympathetic innervation on the endo/lysosomal trafficking of acetylcholine receptor
Regulation of membrane receptors involves management of endocytosis. At the neuromuscular junction, the synapse between skeletal muscle and motoneuron, proper density of the major receptor, the acetylcholine receptor, is of utmost importance for sustaining life in context of mobility. Recent work ha...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-01 | PXD021601 | Pride
Acetylcholine receptor Neuromuscular junction Sympathectomy Sympathetic nervous system Skeletal muscle Endo/lysosomal trafficking 
ProteomicsProteomic analysis links truncated tau to lysosome motility, autophagy and endo-lysosomal dysfunction
Tauopathies are characterized by the progressive accumulation of abnormal tau species, which disrupt the autophagy-lysosomal pathway (ALP), a critical system for degrading intracellular macromolecules and aggregated proteins, causing toxicity and cell death. This study investigates the impact of the...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-22 | PXD062128 | Pride
Tauopathies Toxicity Proteomics Mass spectrometry Autosomal 
ProteomicsEndo-Lysosomal and Ubiquitin CSF Biomarker Discovery by solid-phase extraction and LC-MS/MS
Dysfunctional proteostasis is increasingly implicated in neurodegenerative diseases which is exemplified by an accumulation of protein aggregates in the brain in e.g. Alzheimer's and Parkinson's disease. In addition, in Alzheimer's disease there is an accumulation of autophagic vesicles within neuri...
ORGANISM(S): Homo sapiens (Human) 
2019-09-25 | PXD012851 | Pride
Human Spe Csf Lc-ms/ms 
UnknownThe endo-lysosomal system of bEnd.3 and hCMEC/D3 brain endothelial cells.
Not available
S-EPMC6542060 | biostudies-literature
UnknownThe endo-lysosomal system drives lumen formation in a human epiblast model.
Not available
S-EPMC12340813 | biostudies-literature
UnknownCerebrospinal fluid endo-lysosomal proteins as potential biomarkers for Huntington's disease.
Not available
S-EPMC7430717 | biostudies-literature
UnknownCommon genetic risk for Parkinson's disease and dysfunction of the endo-lysosomal system.
Not available
S-EPMC10874702 | biostudies-literature
UnknownEndo-lysosomal Aβ concentration and pH trigger formation of Aβ oligomers that potently induce Tau missorting.
Not available
S-EPMC8324842 | biostudies-literature
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