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ProteomicsSearching for interactors of endogenous SLX4
The project was aimed at identifying binding partners of endogenous SLX4 in HeLa cells. Whole cell extracts from HeLa Flp-In T-Rex cells were used for immunoprecipitation performed with anti-SLX4 antibodies from Bethyl Laboratories (A302-270A and A302-269A), either used alone or in combination. To d...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD029084 | Pride
Endogenous slx4 Interactome Lc-msms 
ProteomicsIdentifying the N-terminus of SLX4Nter in HeLa KO30 cells
The project was aimed at identifying the N-terminus of a truncated form of SLX4 (termed SLX4Nter) in HeLa KO30 cells. The HeLa KO30 cell line comes from a clone of HeLa Flp-In T-Rex cells (termed FITo) obtained through a CRISPR-Cas9 approach using commercially available plasmids from Santa Cruz Biot...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD029062 | Pride
Crispr-cas9 Slx4 N-terminus acetylation N-terminal truncation 
UnknownRNF168 E3 ligase participates in ubiquitin signaling and recruitment of SLX4 during DNA crosslink repair.
Not available
S-EPMC11388903 | biostudies-literature
UnknownRoles of SLX1-SLX4, MUS81-EME1, and GEN1 in avoiding genome instability and mitotic catastrophe.
Not available
S-EPMC4035540 | biostudies-literature
ProteomicsCIP2A mediates mitotic recruitment of SLX4/MUS81/XPF to replication stress-induced DNA lesions to maintain genome integrity
Perturbed DNA replication can result in genomic regions that remain incompletely replicated at the point that cells enter mitosis. Transmission of replication-mediated DNA lesions into mitosis may prevent proper chromosomes segregation, and cells therefore require mechanisms to resolve these lesions...
ORGANISM(S): Homo sapiens (Human) 
2025-10-23 | PXD059881 | Pride
None 
UnknownUpregulated LINE-1 Activity in the Fanconi Anemia Cancer Susceptibility Syndrome Leads to Spontaneous Pro-inflammatory Cytokine Production.
Not available
S-EPMC4919473 | biostudies-literature
UnknownGEN1/Yen1 and the SLX4 complex: Solutions to the problem of Holliday junction resolution.
Not available
S-EPMC2841330 | biostudies-literature
UnknownEstrogen Aggravates Tumor Growth in a Diffuse Gastric Cancer Xenograft Model.
Not available
S-EPMC8262185 | biostudies-literature
UnknownMms22-Rtt107 axis attenuates the DNA damage checkpoint and the stability of the Rad9 checkpoint mediator.
Not available
S-EPMC11697250 | biostudies-literature
UnknownChromosome-wide histone deacetylation by sirtuins prevents hyperactivation of DNA damage-induced signaling upon replicative stress.
Not available
S-EPMC4824096 | biostudies-literature
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