Sort   by:  
 Page size 
ProteomicsTransmembrane protein 184B (TMEM184B) promotes endolysosomal acidification through vesicular proton pump regulation
Disruption of endolysosomal acidification is a hallmark of several neurodevelopmental and neurodegenerative disorders. Impaired acidification causes accumulation of toxic protein aggregates and disrupts neuronal homeostasis, yet the molecular mechanisms regulating endolysosomal pH in neurons remain ...
ORGANISM(S): Homo sapiens (Human) 
2025-06-16 | PXD064977 | Pride
Vatpase Endolysosomal acidification Tmem184b 
UnknownThe Endolysosomal System and Proteostasis: From Development to Degeneration.
Not available
S-EPMC6209849 | biostudies-literature
UnknownMonitoring the autophagy-endolysosomal system using monomeric Keima-fused MAP1LC3B.
Not available
S-EPMC7279612 | biostudies-literature
ProteomicsThe ER-embedded UBE2J1/RNF26 ubiquitylation complex in spatio-temporal control of the endolysosomal pathwayThe ER-embedded UBE2J1/RNF26 ubiquitylation complex in spatio-temporal control of the endolysosomal pathway
The endolysosomal system fulfills a wide variety of cellular functions, many of which are modulated through interactions with other organelles. In particular, the ER exerts spatiotemporal constraints on the organization and motility of endosomes and lysosomes. We have recently described the ER trans...
ORGANISM(S): Homo sapiens (Human) 
2021-01-22 | PXD022104 | Pride
Endoplasmic reticulum Endosomes Ubiquitin Rnf26 Egfr Ube2j1 
ProteomicsEndolysosomal protease leakage reprograms macrophage mitochondrial metabolism
Organelle crosstalk plays important functions in metabolic processes and is relevant to immunity, neurodegeneration, and cancer. The permeabilisation and rupture of endolysosomes during stress can induce inflammation and cell death. There is growing evidence that endomembrane damage does not always ...
ORGANISM(S): Homo sapiens (Human) 
2022-10-30 | PXD026045 | Pride
Endolysosomal damage Organelle crosstalk Proteomics Mitochondrial metabolic reprogramming 
UnknownInterruption of endolysosomal trafficking leads to stroke brain injury.
Not available
S-EPMC8429234 | biostudies-literature
ProteomicsInhibition of S6K lowers age-related inflammation and immunosenescence and increases lifespan via the endolysosomal system
The nutrient-sensing Target of Rapamycin complex 1 (TORC1) is an evolutionarily conserved regulator of longevity. S6 kinase (S6K) is an essential downstream mediator for the effect of TORC1 on longevity. However, mechanistic insights on how TORC1-S6K signalling promotes lifespan and healthspan are s...
ORGANISM(S): Mus musculus (Mouse) Drosophila melanogaster (Fruit fly) 
2024-01-12 | PXD035293 | Pride
Inhibition of s6k lowers age-related inflammation and immunosenescence and increases lifespan via the endolysosomal system 
UnknownDysfunctional Autophagy and Endolysosomal System in Neurodegenerative Diseases: Relevance and Therapeutic Options.
Not available
S-EPMC7773602 | biostudies-literature
UnknownExpression of N471D strumpellin leads to defects in the endolysosomal system.
Not available
S-EPMC6177004 | biostudies-literature
UnknownNAADP-dependent Ca2+ signaling regulates Middle East respiratory syndrome-coronavirus pseudovirus translocation through the endolysosomal system.
Not available
S-EPMC6251489 | biostudies-literature
Sort   by:  
 Page size