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ProteomicsHow blood matrices and sample preparation can influence blood marker discovery
While plasma and serum are increasingly being studied by using high throughput proteomics, it remains largely unexplored how different types of blood materials collected in the routine clinical diagnostics laboratories influence protein marker discovery. We compared the LC-MS/MS proteomic profiles o...
ORGANISM(S): Homo sapiens (Human) 
2026-01-12 | PXD066304 | Pride
Plasma Speed Mass spectrometry Enrich-ist Serum Lc−ms Ist R package mpwr Data-independent acquisition Perca Mag-net 
ProteomicsPlasma proteomics of ZDF and SD rat using Mag-Net and ENRICH-iST methods
One of the biggest challenges in Plasma Proteomics is to reduce the dynamic range of plasma proteins to capture the expression of low-abundant proteins. Mag-Net and ENRICH-iST methods were evaluated using 20 μL of type 2 diabetes (ZDF) and SD rat plasma by data-independent acquisition (DIA)-MS Mag-N...
ORGANISM(S): Cellular Organisms 
2026-05-20 | PXD067811 | JPOST Repository
ProteomicsEvaluating Protein Enrichment Methods to Improve Biomarker Discovery in Equine Neurological Disorders
This study evaluated and compared three sample preparation strategies for proteomic analysis of equine cerebrospinal fluid (CSF): native in-solution digestion, the ProteoMiner™ Small-Capacity Enrichment Kit (Bio-Rad®), and the PreOmics Enrich-iST™ Kit (PreOmics®). CSF is in direct contact with the c...
ORGANISM(S): Equus caballus (Horse) 
2026-04-13 | PXD063239 | Pride
Cerebrospinal fluid (csf)  proteomics  native digestion  proteominer™ small-capacity enrichment kit  preomics enrich-ist™  liquid chromatography with tandem mass spectrometry (lc-ms/ms) 
ProteomicsImpact of Sample Preparation Strategies on The Quantitative Accuracy of Low-Abundance Serum Proteins in Shotgun Proteomics
Serum proteomics plays a crucial role in biomarker discovery and disease research, yet the selection of an optimal sample preparation method remains challenging. Evaluating the accuracy of protein quantitation is of major importance and a vital part of a benchmarking study in proteomics, since clini...
ORGANISM(S): Homo sapiens (Human) 
2025-09-15 | PXD062785 | Pride
Reproducibility Quantitative accuracy Serum proteomics Depth of coverage 
UnknownBlood Matrices and Sample Preparation Influence Blood Marker Discovery.
Not available
S-EPMC12772121 | biostudies-literature
UnknownImpact of Sample Preparation Strategies on the Quantitative Accuracy of Low-Abundance Serum Proteins in Shotgun Proteomics.
Not available
S-EPMC12418494 | biostudies-literature
ProteomicsMethod testing for plasma proteomics
We have compared the plasma proteome coverage obtained by using different methods for samplepreparation
ORGANISM(S): Homo sapiens (Human) 
2026-06-29 | PXD057402 | Pride
Ev Dia Depletion Plasma 
ProteomicsProteomics Data of "Integrated Clinical Trial and Molecular Profiling Reveals Immune Drivers of Chronic Hand Eczema" Study
Background: Chronic hand eczema (CHE) is a debilitating skin condition characterized by pain, itch, and chronic inflammation, with a complex multifactorial origin. Its diverse presentations, including overlapping traits of atopic dermatitis, contact dermatitis, and psoriasis, make diagnosis and trea...
ORGANISM(S): Homo sapiens (Human) 
2026-02-26 | PXD059218 | Pride
ProteomicsBenchmarking plasma from clinical and preclinical models
The push for new clinical biomarkers has seen rapid innovation in biofluid analysis, particularly for plasma. For mass-spectrometry (MS)-based analysis, achieving depth and quantitative accuracy whilst ensuring throughput continues to shape plasma methods development. Numerous workflows have emerged...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2026-07-27 | PXD072131 | Pride
Human Dia Serum Plasma Rat Orbitrap astral 
ProteomicsProteome of renal tubuli and serum differentiate pre-existing type 2 diabetes and post-transplant diabetes in kidney transplant recipients
This study explores these differences by comparing the proteomes of proximal tubules and serum from normoglycemic (NG), pre-transplant T2DM, and PTDM patients one-year post-kidney transplantation.
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD054961 | Pride
Serum 
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