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Membrane-bound particles in plasma are composed of exosomes, microvesicles, and apoptotic bodies and represent ~1-2% of the total protein composition. Proteomic interrogation of this subset of plasma proteins augments the representation of tissue-specific proteins, representing a “liquid biopsy,” wh...
ORGANISM(S): Homo Sapiens 
One of the biggest challenges in Plasma Proteomics is to reduce the dynamic range of plasma proteins to capture the expression of low-abundant proteins. Mag-Net and ENRICH-iST methods were evaluated using 20 μL of type 2 diabetes (ZDF) and SD rat plasma by data-independent acquisition (DIA)-MS Mag-...
ORGANISM(S): Cellular Organisms 
Discovery proteomics of plasma samples from ChILI patients. EV enrichment was performed using Mag-Net protocol and samples were labelled with TMTpro.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-01-24 | MSV000096928 | MassIVE
Plasma is an ideal material for proteomics due to its diverse protein content reflecting physiological and pathological states, and its compatibility with minimally invasive sampling. Deep proteomic profiling of plasma is limited by high-abundant proteins that mask the detection of low-abundant prot...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-05-05 | MSV000097796 | MassIVE
While plasma and serum are increasingly being studied by using high throughput proteomics, it remains largely unexplored how different types of blood materials collected in the routine clinical diagnostics laboratories influence protein marker discovery. We compared the LC-MS/MS proteomic profiles o...
ORGANISM(S): Homo sapiens (Human) 
2026-01-12 | PXD066304 | Pride
We report a technical evaluation of six notable plasma proteomics technologies from recent years. Unenriched plasma, perchloric acid depletion, PreOmics ENRICHplus, Mag-Net, Seer Proteograph XT, and Olink Explore HT. The methods were compared on proteomic depth, reproducibility, linearity, tolerance...
ORGANISM(S): Homo sapiens (Human) Gallus gallus (Chicken) 
2025-05-12 | PXD060573 | Pride
We report a technical evaluation of six notable plasma proteomics technologies from recent years. Unenriched plasma, perchloric acid depletion, PreOmics ENRICHplus, Mag-Net, Seer Proteograph XT, and Olink Explore HT. The methods were compared on proteomic depth, reproducibility, linearity, tolerance...
ORGANISM(S): Homo sapiens (Human) 
2025-05-12 | PAD000002 | Pride
The development of targeted assays that monitor biomedically relevant proteins is an important step in bridging discovery experiments to large scale clinical studies. Targeted assays are currently unable to scale to hundreds or thousands of targets. We demonstrate the generation of large-scale assay...
ORGANISM(S): Homo Sapiens Gallus Gallus 
2026-01-12 | PXD065471 | panorama
We report a technical evaluation of six notable plasma proteomics technologies from recent years. Unenriched plasma, perchloric acid depletion, PreOmics ENRICHplus, Mag-Net, Seer Proteograph XT, and Olink Explore HT. The methods were compared on proteomic depth, reproducibility, linearity, tolerance...
ORGANISM(S): Gallus Gallus (ncbitaxon:9031) Homo Sapiens (ncbitaxon:9606) 
2026-02-23 | MSV000100943 | MassIVE
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