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MetabolomicsAnalysis of Growth Phases of Enterotoxigenic Escherichia coli Reveals a Distinct Transition Phase before Entry into Early Stationary Phase with Shifts in Tryptophan, Fucose, and Putrescine Metabolism and Degradation of Neurotransmitter Precursors

Enterotoxigenic Escherichia coli (ETEC) is a major cause of diarrhea in children and adults in endemic areas. Gene regulation of ETEC during growth in vitro and in vivo needs to be further evaluated, and here we describe the full transcriptome and metabolome of ETEC dur...

2022-07-15 | MTBLS3540 | MetaboLights
MetabolomicsComparative Transcriptome and Energy Metabolome Profiling Unravel the Key Role of GlcN6P Metabolic Pathway in Resistance against Bacteriophage in Enterotoxigenic Escherichia coli

The rapid emergence of phage-resistant bacterial mutants is a major challenge for phage application in the food industry. The resistance mechanisms of Enterotoxigenic E. coli (ETEC) against phage infection are largely unknown. In Escherichia coli, RapZ regulates gluc...

2025-12-15 | MTBLS13411 | MetaboLights
MetabolomicsLacto-N-tetraose mediates indole-3-lactic acid production by Bifidobacterium longum subsp. infantis to alleviate enterotoxigenic Escherichia coli-induced diarrhea in infants

Enterotoxigenic Escherichia coli (ETEC) is a leading cause of infectious diarrhea and poses a threat to infant health. Current treatments for ETEC infection primarily rely on antibiotics，which face limitations due to resistance and side effect. In this cross-sectional study, we analyzed fecal met...

2025-08-24 | MTBLS12886 | MetaboLights
GenomicsChIP-seq of the multiple antibiotic resistance repressor (MarR) protein of Enterotoxigenic Escherichia coli strain H10407
The experiment contains ChIP-seq data for Enterotoxigenic Escherichia coli strain H10407 transformed with plasmids pAMNF (encoding an N-terminal MarR-3xFLAG fusion) or pAMNM (encoding an N-terminal MarR-8xmyc fusion). The cells was cultured at 37 degrees in LB medium and crosslinked with 1 % (v/v) f...
ORGANISM(S): Escherichia coli 
2017-12-01 | E-MTAB-5591 | biostudies-arrayexpress
GenomicsChIP-seq of the multiple antibiotic resistance activator (MarA) protein and RNA polymerase sigma70 subunit of Enterotoxigenic Escherichia coli strain H10407
The experiment contains ChIP-seq data for Enterotoxigenic Escherichia coli strain H10407 transformed with plasmid pRGM9818. The strain was grown at 37 degrees in LB medium and crosslinked with 1 % (v/v) formaldehyde. After sonication, to break open cells and fragment DNA, immunoprecipitations were d...
ORGANISM(S): Escherichia coli 
2017-09-30 | E-MTAB-5521 | biostudies-arrayexpress
TranscriptomicsGlobal transcriptomics of enterotoxigenic E. coli strain E24377A
ETEC is an important human pathogen. Although the mechanism of diarrhea is known in ETEC, the regulatory networks are less understood. This study was conducted to understand the global expression of ETEC isolate E24377A under different growth and environmental conditions. ETEC E24377A was grown in...
ORGANISM(S): Escherichia coli E24377A 
2012-03-01 | E-GEOD-31805 | biostudies-arrayexpress
ProteomicsImproving Genome Annotation of Enterotoxigenic Escherichia coli TW10598 by a Label-Free Quantitative MS/MS Approach
The most commonly used genome annotation processes are to a great extent based on computational methods. However, those can only predict genes that have been described earlier or that have sequence signatures indicative of a gene function. We reported a synonymous proteogenomic approach for experime...
ORGANISM(S): Escherichia coli 
2015-09-15 | PXD002473 | Pride
Synonymous proteogenomics Enterotoxigenic escherichia coli Label-free quantification Genome annotation 
TranscriptomicsCharacterization of probiotic Escherichia coli isolates using a novel pangenome microarray
Background: Based on 32 Escherichia coli and Shigella genome sequences, we have developed an E. coli pan-genome microarray. Publicly available genomes were annotated in a consistent manor to define all currently known genes potentially present in the species. The chip design was evaluated by hybridi...
ORGANISM(S): Escherichia coli 
2010-05-26 | E-GEOD-8595 | biostudies-arrayexpress
ProteomicsIntestinal proteomic response to oral challenge of enterotoxigenic Escherichia coli in weaned pigs
Enterotoxigenic Escherichia coli (ETEC) is a major cause of diarrhoea in children in resource-limited countries and of travellers diarrhoea. The ileal proteomics change after ETEC challenge is less characterised. Here in this study changes of ileal proteins post ETEC challenge in weaned pigs are stu...
ORGANISM(S): Sus scrofa (Pig) 
2022-04-01 | PXD028066 | Pride
Infant diarrhea  enterotoxigenic escherichia coli  proteomics  ileum  sus scrofa 
ProteomicsProteomics of Diverse Clonal Groups of Enterotoxigenic Escherichia coli Underline Variations in Surface Antigens and Similarities in Metabolism
Enterotoxigenic Escherichia coli (ETEC) is an important cause of diarrhoea, a pervasive disease in low- and middle-income countries that affects mostly young children and visiting travellers. Substantial diversity exists among ETEC isolates, hindering development of effective preventive means. To in...
ORGANISM(S): Escherichia coli 
2017-12-06 | PXD005259 | Pride
Bacterial metabolism Virulence Proteogenomics H10407 Label-free quantification Plasmid Enterotoxigenic escherichia coli 
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