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ProteomicsEpstein-Barr Virus Induced One-Carbon Metabolism Drives B-Cell Transformation
Epstein-Barr virus (EBV) causes Burkitt, Hodgkin, and post-transplant B-cell lymphomas. How EBV remodels metabolic pathways to support rapid B-cell outgrowth remains largely unknown. To gain insights, primary human B-cells were profiled by tandem-mass-tag based proteomics at rest and at 9 time point...
ORGANISM(S): Homo sapiens (Human) Epstein-barr virus strain p3hr-1 
2019-06-28 | PXD013034 | Pride
Herpesvirus One-carbon metabolism Epstein-barr virus Host-pathogen interaction Quantitative proteomics Tandem mass tag 
TranscriptomicsDownregulation of integrin receptor signalling genes by EBV EBNA 3C
Comparsion of cellular gene expression between a control B lymphoma cell-line (BJAB pz2) stably transfected with an empty vector and a BJAB cell-line stably expressing Epstein-Barr virus EBNA 3C (BJAB E3C-4). These cell lines are described in Wang, F., C. Gregory, C. Sample, M. Rowe, D. Liebowitz, R...
ORGANISM(S): Homo sapiens 
2012-03-13 | E-MEXP-3585 | biostudies-arrayexpress
ProteomicsA Temporal Proteomic Map of Epstein-Barr Virus Lytic Replication in B-cells
Epstein Barr virus (EBV) replication contributes to multiple human diseases, including infectious mononucleosis, nasopharyngeal carcinoma, B-cell lymphomas, and oral hairy leukoplakia. We performed systematic quantitative analyses of temporal changes in host and EBV proteins during lytic replication...
ORGANISM(S): Homo sapiens (Human) 
2017-05-19 | PXD006317 | Pride
B-cell receptor Immune evasion Herpesvirus Complement Viral evasion Epstein-barr virus Lytic replication Host-pathogen interaction Quantitative proteomics Tandem mass tag 
GenomicsModulation of enhancer looping and differential gene targeting by Epstein-Barr virus transcription factors directs epigenetic reprogramming
Epstein-Barr virus (EBV) epigenetically reprogrammes B-lymphocytes to drive immortalization and facilitate viral persistence. Host-cell transcription is perturbed principally through the actions of EBV EBNA 2, 3A, 3B and 3C, with cellular genes deregulated by specific combinations of these EBNAs thr...
ORGANISM(S): Homo sapiens 
2013-09-13 | E-GEOD-47629 | biostudies-arrayexpress
ProteomicsAn Epstein–Barr Virus Protein Interaction Map Reveals NLRP3 Inflammasome Evasion Via MAVS UFMylation
Epstein-Barr virus (EBV) causes infectious mononucleosis, triggers multiple sclerosis and is associated with 200,000 cancers/year. EBV colonizes the B-cell compartment and periodically reactivates, inducing expression of 80 viral proteins. Yet much remains unknown about how EBV remodels host cells a...
ORGANISM(S): Viruses Homo sapiens (Human) 
2023-07-20 | PXD041336 | Pride
Innate immunity Gasdermin d Ufmylation Herpesvirus Mitochondrial-derived vesicles Herpesvirus replication Viral g-protein coupled receptor Nlrp3 inflammasome Antiviral defense Interactome Interleukin-1-beta 
ProteomicsThe B Cell Repertoire in Multiple Sclerosis Reveals Molecular Mimicry between EBNA1 and GlialCAM
This data set contains the mass spectrometry raw files for the paper The B Cell Repertoire in Multiple Sclerosis Reveals Molecular Mimicry between EBNA1 and GlialCAM. In multiple sclerosis (MS) intrathecal B lymphocytes are directly involved in inflammation and secrete oligoclonal immunoglobulin. Ho...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-02-11 | MSV000086842 | MassIVE
TranscriptomicsTHOC5, a member of the mRNA export complex, is essential for hematopoiesis in vivo and is required for CSF-1 induced macrophage differentiation
THOC5, a member of the mRNA export complex, is essential for hematopoiesis in vivo and is required for CSF-1 induced macrophage differentiation, thereby playing a key role in the mRNA export of immediate early genes induced by CSF-1 stimulation. Hematopoiesis, growth, differentiation, and commitment...
ORGANISM(S): Mus musculus 
2013-12-24 | E-GEOD-41170 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA-seq of isolated human foetal L/M-opsin cone photoreceptor populations labelled using the AAV2/9.pR2.1.GFP reporter
Human cone photoreceptors represent a rare cell population of the human retina and are largely outnumbered by other retinal cell types. Despite their rarity, cone photoreceptors are critical for optimal daylight vision and their loss has the greatest impact on sight during the progression of retinal...
ORGANISM(S): Homo sapiens 
2018-04-20 | E-MTAB-6058 | biostudies-arrayexpress
TranscriptomicsKDM6B-induced gene expression changes in transfected CD10-positive GC B cells
In this study, we have investigated the effect of lysine-specific demethylase 6B (KDM6B) on gene expression in normal human germinal center (GC) B cells using a non-viral vector-based system. Gene expression was compared between KDM6B-transfected and control vector-transfected GC B cells from three ...
ORGANISM(S): Homo sapiens 
2011-07-26 | E-GEOD-24044 | biostudies-arrayexpress
TranscriptomicsmicroRNA profiling of root tissues and root forming explant cultures in Medicago truncatula
To identify key miRNAs involved in root meristem formation in M. truncatula, deep sequencing was used to compare the miRNA populations dreived from four tissues. These were; root tip tissue, containing the root apical meristem, elongation zone tissue, root forming callus tissue and non-root formi...
ORGANISM(S): Medicago truncatula 
2013-04-03 | E-GEOD-45726 | biostudies-arrayexpress
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