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TranscriptomicsBipolar and schizophrenia risk gene AKAP11 encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to synaptic transmission
Human genomic studies have identified protein-truncating variants in AKAP11 associated with both bipolar disorder (BD) and schizophrenia (SCZ), implicating a shared disease mechanism driven by loss-of-function. AKAP11, a protein kinase A (PKA) adaptor, plays a key role in degrading the PKA-RI comple...
ORGANISM(S): Mus musculus 
2025-12-09 | GSE304457 | GEO
UnknownBipolar and schizophrenia risk gene AKAP11 encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to synaptic transmission.
Not available
S-EPMC12663438 | biostudies-literature
GenomicsBipolar and schizophrenia risk gene AKAP11 encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to synaptic transmission
Bipolar and schizophrenia risk gene AKAP11 encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to synaptic transmission
PRJNA1301334 | ENA
ProteomicsBipolar and schizophrenia risk gene AKAP11 encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to synaptic transmission
AKAP11 deficiency is associated with autophagy-regulated PKA and neuronal activity in mouse brains. We hypothesized that the differentially expressed proteins (DEPs) and phospho-proteins (pDEPs) in AKAP11 conditional KO mice and human iPSC-induced neurons (iNs) could be identified as potential AKAP1...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-12-08 | PXD067156 | Pride
Mouse models Synaptic transmission Er-resident autophagy-related proteins vapa/b Bipolar disorder (bd) Protein kinase a (pka) Pka-ri. Electrophysiology Akap11 Multi-omics Cell biology Schizophrenia (scz) Human induced neurons Gsk3a/b Sphkap 
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