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ProteomicsThe ERK5 signalling pathway employs a KLF2-ZSCAN4 auto-regulatory module to induce embryonic 2-cell stage genes
The ERK5 MAP kinase signalling pathway was recently discovered as a driver of naïve pluripotency in mouse Embryonic Stem Cells (mESCs). However, the molecular functions of ERK5 in mESCs have not been investigated. Here, we employ combinatorial mESC proteomics to identify ERK5 target genes and substr...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-29 | PXD010581 | Pride
Mass spectrometry Phosphoproteomic Tmt Erk5 
GenomicsThe signalling axis ERK5/KLF2 is a major determinant of chemical sarcomagenesis
The signalling axis ERK5/KLF2 is a major determinant of chemical sarcomagenesis
PRJNA819871 | ENA
TranscriptomicsERK5 Regulates Muscle Cell Fusion through Klf Transcription Factors
In skeletal muscle differentiation, muscle-specific genes are regulated by two groups of transcription factors, the MyoD and MEF2 families, which work together to drive the differentiation process. Here we show that ERK5 regulates muscle cell fusion through Klf transcription factors. The inhibition ...
ORGANISM(S): Mus musculus 
2011-02-21 | E-GEOD-25827 | biostudies-arrayexpress
TranscriptomicsThe signalling axis ERK5/KLF2 is a major determinant of chemical sarcomagenesis
Sarcomas are a heterogeneous group of tumors in which the role of ERK5 is poorly studied. To clarify the role of this particular MAPK in sarcomatous pathology, we used a murine 3-methyl-cholanthrene (3MC)-induced sarcoma model. Our data show that 3MC induces pleomorphic sarcomas with muscle differen...
ORGANISM(S): Mus musculus 
2022-08-03 | GSE199395 | GEO
UnknownMechanosensitive Channel PIEZO1 Senses Shear Force to Induce KLF2/4 Expression via CaMKII/MEKK3/ERK5 Axis in Endothelial Cells.
Not available
S-EPMC9317998 | biostudies-literature
ProteomicsAn ERK5-KLF2 signalling module regulates early embryonic gene expression dynamics and stem cell rejuvenation
CCE mESCs were transfected with either empty pCAGGS vector or HA-MEK5DD (S311D T315D) construct for 48 hours. 24 hours prior to lysis, mESCs were either treated with 10uM AX15836 or DMSO control, and transfected mESCs selected with puromycin. Conditions were performed in triplicate.
ORGANISM(S): Mus musculus (Mouse) 
2021-03-18 | PXD024679 | Pride
Erk5-klf2 Embryonic gene expression Tmt Stem cell rejuvenation Lc-ms Mass spectrometry Signalling 
UnknownA20/TNFAIP3 Increases ENOS Expression in an ERK5/KLF2-Dependent Manner to Support Endothelial Cell Health in the Face of Inflammation.
Not available
S-EPMC8138474 | biostudies-literature
TranscriptomicsERK5 Regulates Muscle Cell Fusion through Klf Transcription Factors
In skeletal muscle differentiation, muscle-specific genes are regulated by two groups of transcription factors, the MyoD and MEF2 families, which work together to drive the differentiation process. Here we show that ERK5 regulates muscle cell fusion through Klf transcription factors. The inhibition ...
ORGANISM(S): Mus musculus 
2011-02-21 | GSE25827 | GEO
UnknownFlow activation of AMP-activated protein kinase in vascular endothelium leads to Kruppel-like factor 2 expression.
Not available
S-EPMC2766008 | biostudies-literature
UnknownPKCzeta decreases eNOS protein stability via inhibitory phosphorylation of ERK5.
Not available
S-EPMC3173991 | biostudies-literature
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