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GenomicsRepressive and active histone methylation mark distinct promoters in human and mouse spermatozoa (Illumina)
In higher eukaryotes, histone methylation is involved in the maintenance of cellular identity during somatic development. During spermatogenesis, Since most nucleosomes are replaced by protamines during spermatogenesis . Iit is therefore unclear whether if histone modifications function in paternal ...
ORGANISM(S): Homo sapiens 
2010-05-16 | E-GEOD-19889 | biostudies-arrayexpress
GenomicsProper chromatin programming during spermatogenesis is required for embryonic development
Epigenetic mechanisms including DNA methylation, non-coding RNAs and histone modifications control gene expression. Studies suggest that a father's lifetime experiences can be transmitted to his offspring to affect development and health. The mechanisms underlying such epigenetic inheritance are unk...
ORGANISM(S): Mus musculus 
2015-11-03 | E-GEOD-55471 | biostudies-arrayexpress
ProteomicsFLI1 and FRA1 transcription factors drive the transcriptional regulatory networks characterizing muscle invasive bladder cancer
Identification of transcriptional regulatory networks in muscle invasive and non-muscle invasive bladder cancer cell lines
ORGANISM(S): Homo sapiens (Human) 
2023-02-17 | PXD028665 | Pride
Enhancer Transcriptional regulation Bladder cancer Fli1 Fra1 
GenomicsPerturbed adult sperm methylome after in utero undernutrition is associated with transmission of metabolic disease
The pre and postnatal environment can affect both an individual’s risk of adult onset metabolic disease and that of subsequent generations. Although animal models and epidemiological data implicate epigenetic inheritance, little is known of the mechanisms involved. In a robust intergenerational mo...
ORGANISM(S): Mus musculus 
2014-07-16 | E-GEOD-58747 | biostudies-arrayexpress
GenomicsDensity and methylation state of CpG dinucleotides define histone variant specific retention of nucleosomes in mouse spermatozoa
Nucleosomes are the principal packaging units of chromatin and critical for gene regulation and genome stability. In mammals, a subset of nucleosomes fail to be replaced by protamines during spermatogenesis and are retained in mature spermatozoa providing opportunities for paternal epigenetic transm...
ORGANISM(S): Mus musculus 
2013-06-15 | E-GEOD-42629 | biostudies-arrayexpress
GenomicsSperm is epigenetically programmed to regulate gene transcription in embryo
Using the frog Xenopus laevis as a model system we profile epigenetic features of sperm and spermatid to study how they relate to gene expression in embryos. We observe that sperm is epigenetically programmed to regulate embryonic gene expression. By comparing the development of sperm- and spermatid...
ORGANISM(S): Xenopus laevis 
2016-03-22 | E-GEOD-75164 | biostudies-arrayexpress
Genomicsena-DATASET-dkfz_b062-23-02-2018-16:41:10:412-192 - samples
This dataset contains ChIP sequencing data from 24 patients. ChIP of 5–10 mg flash-frozen primary ependymoma tumour was performed using 5 mg H3K27ac antibody per ChIP experiment. The enriched DNA has been sequenced on a Illumina HiSeq2000 instrument in paired-end mode. Up to two lanes per sampl...
EGAD00001003979 | EGA
Genomicsena-DATASET-dkfz_b062-16-02-2018-17:18:40:151-347 - samples
This dataset conatains RNA sequencing data from 24 patients. Up to two lanes per tumour sample have been seqeunced on a Illumina HiSeq2000 instrument in paired-end mode resulting in 58 Fastq files.
EGAD00001003966 | EGA
Genomicsena-DATASET-dkfz_b062-31-01-2018-17:04:38:652-360 - samples
This dataset contains whole genome sequencing data from 24 patients. For each patient a tumour and control sample has been sequenced on a Illumina HiSeq2000 instrument in paired-end mode. Up to three lanes per sample have been sequenced resulting in 112 Fastq files.
EGAD00001003940 | EGA
Genomicsc5317816-0376-4b3d-82db-2d14d36dc8ea - samples
This dataset contains Whole Genome Bisulfite sequencing data from seven samples (six tumor samples and on tumor derived cell line). Sequencing was performed Illumina HiSeq 2000 machine resulting in 14 FASTQ files.
EGAD00001008805 | EGA
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