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TranscriptomicsEscherichia coli global gene expression due ciprofloxacin challenge in human whole blood
Treatment failures of antibiotic therapy are of major concern and can be caused by a misalignment of the antibiotic susceptibility determined in vitro with the behaviour of the pathogen in the patient. The aim of this study was to investigate the transcriptomic response of the uropathogenic strain E...
ORGANISM(S): Escherichia coli CFT073 
2016-04-01 | E-GEOD-68106 | biostudies-arrayexpress
TranscriptomicsEscherichia coli global gene expression due ciprofloxacin challenge in laboratory medium and human serum
Treatment failures of antibiotic therapy are of major concern and can be caused by a misalignment of the antibiotic susceptibility determined in vitro with the behaviour of the pathogen in the patient. The aim of this study was to investigate the transcriptomic response of the uropathogenic strain E...
ORGANISM(S): Escherichia coli CFT073 
2016-04-01 | E-GEOD-68105 | biostudies-arrayexpress
ProteomicsSOS Genes Are Rapidly Induced While Mutagenesis Is Temporally Regulated by Changes in Protein Activation and Nucleotide Pools After a Sub-lethal Dose of Ciprofloxacin in Escherichia coli
The DNA damage inducible SOS response in bacteria serves to increase survival of the species. The SOS response first initiates error-free repair which is followed by error-prone repair. Here, we have employed a multi-omics approach to elucidate the temporal coordination of the SOS response using tra...
ORGANISM(S): Escherichia coli 
2024-03-26 | PXD047394 | Pride
Signalomics Escherichia coli Ciprofloxacin Sos response 
TranscriptomicsPlasticity of transcriptional regulation under antibiotic stress
Evolution of antibiotic resistance in microbes is frequently achieved by acquisition of spontaneous mutations during antimicrobial therapy. Here we demonstrate that inactivation of a central regulator of iron homeostasis (fur) facilitates laboratory evolution of ciprofloxacin resistance in Escherich...
ORGANISM(S): Escherichia coli K-12 
2014-09-11 | E-GEOD-55662 | biostudies-arrayexpress
TranscriptomicsTranscriptional Response to Ciprofloxacin in Enteropathogenic Escherichia coli Deng
We employed a genome-wide microarray approach to obtain a profile of the transcriptional events in ciprofloxacin-treated EPEC shedding light on how ciprofloxacin affects EPEC transcriptional events and growth, aside from resistance mechanisms, and how this bacterium tolerates antibiotic stress. Samp...
ORGANISM(S): Escherichia coli 
2015-12-15 | E-GEOD-75988 | biostudies-arrayexpress
GenomicsEscherichia coli
Impact of epicatechin on ciprofloxacin resistance evolution in Escherichia coli
PRJNA1438117 | ENA
ProteomicsProteomics Analysis of Evolved Escherichia coli Populations from Cyclic Antibiotic Treatment
When the survivors of antibiotic treatment (persisters) are repeatedly regrown and retreated with the same antibiotic for several cycles, the new population will soon adapt to the treatment condition and become tolerant to the drug. Here, we did evolution experiments on Escherichia coli populations ...
ORGANISM(S): Escherichia coli 
2020-01-10 | PXD013326 | Pride
Proteomics Persistence Antibiotic Persisters Evolved populations 
TranscriptomicsRNA-seq analyzes the effect of purA on transcriptome in Escherichia coli during ciprofloxacin treatment.
PurA encodes an adenylosuccinate synthetase that catalyzes the first step in the de novo synthesis of AMP. A deficiency in purA has been found to confer Escherichia coli tolerance to diverse types of antibiotics. To understand the molecular basis of the increased tolerance, we performed RNA-seq anal...
ORGANISM(S): Escherichia coli 
2025-03-25 | GSE292923 | GEO
ProteomicsImpact of suppression of the SOS response on protein expression in clinical isolates of Escherichia coli under antimicrobial pressure of ciprofloxacin
Suppression of the SOS response in combination with drugs has been proposed as a potential target to tackle antimicrobial resistance. The SOS response is the pathway used to repair bacterial DNA damage induced by antimicrobials such as quinolones. The extent of lexA-regulated protein expression and...
ORGANISM(S): Escherichia coli 
2024-04-04 | PXD050358 | Pride
Escherichia coli. ciprofloxacin 
ProteomicsGlobal protein responses of multi-drug resistant plasmid containing Escherichia coli to beta-lactams and ciprofloxacin.
Our study aimed to analyse the responses of the clonal ST131 strain, containing the ESBL and multi-drug resistance plasmid under different beta-lactam and ciprofloxacin antibiotic stress in comparison with no antibiotic stresses in order to identify the specific response of a MDR plasmid to the spec...
ORGANISM(S): Escherichia coli 
2022-10-12 | PXD027164 | Pride
Antibiotics Proteomics E. coli Anti microbial resistance 
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