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ProteomicsA SIRT7-dependent acetylation switch regulates early B-cell differentiation and lineage commitment through PAX5
B lymphopoiesis is a key developmental event orchestrated by a complex combinatorial action of lineage-specific transcription factors. In early B cell progenitors, lineage commitment is directly mediated by the master regulator PAX5, whose deficiency is commonly associated with B cell Acute Lymphobl...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-20 | PXD046457 | Pride
Sirtuins Sirt7 Acetylation Pax5 B cell progenitors Pre-b cell Hematopoiesis Immunoaffinity 
TranscriptomicsBRAF-induced tumorigenesis is IKKalpha dependent but NF?B independent
Tumor cells carrying KRAS mutations activate the NF-?B pathway by different mechanisms, which contribute to the acquisition of essential cancer properties. The BRAF kinase, a downstream mediator of KRAS, is also mutated in a subset of colorectal cancers (CRC), which predicts bad prognosis and therap...
ORGANISM(S): Homo sapiens 
2015-05-08 | E-GEOD-57979 | biostudies-arrayexpress
UnknownOxidative Stress Induced by the Deubiquitinase Inhibitor b-AP15 Is Associated with Mitochondrial Impairment.
Not available
S-EPMC6590552 | biostudies-literature
TranscriptomicsComparison of Tn-seq of Escherichia coli using B-2163 and MFDpir as donor strains.
To perform Tn-seq experiments random distribution of the transposon in the genome of the recipient cells is essential. In case transposon is delivered into the host cell by conjugation, donor may affect the distribution of the transposon in the genome of the recipient cell. Here, we provide two Tn-s...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2020-11-12 | E-MTAB-9713 | biostudies-arrayexpress
UnknownEfficient synthesis of B-alkylated oxazaborolidines derived from ephedrine and norephedrine.
Not available
S-EPMC2811074 | biostudies-literature
TranscriptomicsThe Notch/Hes1 pathway sustains NF-M-NM-:B activation through CYLD repression in T cell leukemia
The NF-M-NM-:B pathway is a critical regulator of the immune system and has been implicated in cellular transformation and tumorigenesis. NF-M-NM-:B response is regulated by the activation state of the IM-NM-:B kinase (IKK) complex and triggered by a wide spectrum of stimuli. We previously reported ...
ORGANISM(S): Homo sapiens 
2011-05-07 | E-GEOD-20667 | biostudies-arrayexpress
UnknownImmune-derived cardiac autonomic signatures: predicting autonomic responses to exercise from B-cell phenotypes.
Not available
S-EPMC12851968 | biostudies-literature
UnknownProlactin decreases LPS-induced inflammatory cytokines by inhibiting TLR-4/NFκB signaling in the human placenta.
Not available
S-EPMC6821386 | biostudies-literature
UnknownHyperglycemia enhances group B <i>Streptococcus</i> pathogenicity by impairing TLR2 expression and chemotactic response in the human placenta.
Not available
S-EPMC12310592 | biostudies-literature
UnknownA SIRT7-dependent acetylation switch regulates early B cell differentiation and lineage commitment through Pax5.
Not available
S-EPMC11588656 | biostudies-literature
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