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MetabolomicsThe patatin-like protein PlpD forms novel structurally dynamic homodimers in the Pseudomonas aeruginosa outer membrane

Members of the Omp85 superfamily of outer membrane proteins (OMPs) found in Gram-negative bacteria, mitochondria and chloroplasts are characterized by a distinctive 16-stranded β-barrel transmembrane domain and at least one periplasmic POTRA domain. All previously studied Omp85 proteins promote c...

2025-12-08 | MTBLS9803 | MetaboLights
TranscriptomicsFunction, targets and evolution of Caenorhabditis elegans piRNAs
This SuperSeries is composed of the following subset Series: GSE28617: Function, targets and evolution of Caenorhabditis elegans piRNAs (small RNA-Seq) GSE37432: Function, targets and evolution of Caenorhabditis elegans piRNAs (mRNA) Refer to individual Series
ORGANISM(S): Caenorhabditis elegans 
2012-06-17 | E-GEOD-37433 | biostudies-arrayexpress
GenomicsConserved Function of lincRNAs in Vertebrate Embryonic Development Despite Rapid Sequence Evolution
Thousands of large intervening non-coding RNAs (lincRNAs) have been identified in mammals. To better understand the evolution and functions of these enigmatic RNAs, we used chromatin marks, poly(A)-site mapping and RNA-Seq data, to identify more than 550 distinct lincRNAs in zebrafish. Although thes...
ORGANISM(S): Danio rerio 
2011-12-22 | E-GEOD-32880 | biostudies-arrayexpress
TranscriptomicsRAS/MAPK activation drives resistance to Smo inhibition, metastasis and tumor evolution in Shh pathway-dependent tumors
Aberrant Shh signaling promotes tumor growth in diverse human cancers. The importance of Shh signaling is particularly evident in medulloblastoma and basal cell carcinoma (BCC), where inhibitors targeting the Shh pathway component Smoothened (Smo) show great therapeutic promise. However, the emergen...
ORGANISM(S): Mus musculus 
2015-07-22 | E-GEOD-69359 | biostudies-arrayexpress
GenomicsSupression of genetic recombination in the pseudoautosomal region and at subtelomeres in mice with a hypomorphic spo11 allele
Homologous recombination is the key process that generates genetic diversity and drives evolution. SPO11 protein triggers recombination by introducing DNA double stranded breaks at discreet areas of the genome called recombination hotspots. The hotspot locations are largely determined by the DNA bin...
ORGANISM(S): Mus musculus 
2013-09-11 | E-GEOD-48493 | biostudies-arrayexpress
TranscriptomicsWhole-genome resequencing of Pseudomonas aeruginosa PAO1 after anti-virulence treatments targeting iron uptake
We carried out an experimental evolution in human serum as an ex-vivo model and screened evolved lines for the evolution of resistance phenotypes towards two anti-virulence treatments, gallium and flucytosine, which both target the iron scavenging pyoverdine of Pseudomonas aeruginosa (each at 2 diff...
ORGANISM(S): Pseudomonas aeruginosa 
2018-09-07 | E-MTAB-6110 | biostudies-arrayexpress
UnknownEvolutionary Refinement of Mitochondrial and Plastid Targeting Sequences Coincides with the Late Diversification of Land Plants.
Not available
S-EPMC12531127 | biostudies-literature
ProteomicsAlternative start codon selection shapes mitochondrial function during evolution, homeostasis, and disease
Mitochondrial acquisition was a pivotal event in eukaryotic evolution, requiring core proteins adapt to function both within the mitochondria and in the host cell. Here, we systematically profile the localization of protein isoforms generated by alternative start codon selection. We identify hundred...
ORGANISM(S): Homo sapiens (Human) 
2025-10-28 | PXD062112 | Pride
Mrps38 Ribosomes Mitochondria Aurkaip1 
UnknownRole of accelerated segment switch in exons to alter targeting (ASSET) in the molecular evolution of snake venom proteins.
Not available
S-EPMC2711939 | biostudies-literature
ProteomicsConvergent origin and accelerated evolution of vesicle-associated RhoGAP proteins in two unrelated parasitoid wasps
Gene duplication, accompanied by modification of the expression and/or function of one of the duplicates under the action of positive selection, followed by further duplication to produce multigene families of toxins is a well-documented process in venomous animals. This evolutionary model has been ...
ORGANISM(S): Leptopilina boulardi Leptopilina heterotoma 
2023-06-09 | PXD041695 | Pride
Gene duplication Venom Evolution Positive selection Parasitoids Rhogap Ovarian calyx 
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