Excitatory synapse

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Single-Cell Extraction: For enzymatic digestion, pronase (Septomyces argeus, 1 mg/mL) was applied for 25 minutes at room temperature for P0 to P8 datasets. Cells were dissociated and triturated into a single-cell suspension in ACSF supplemented with 1% fetal calf serum (FCS) and DNase (1 µL/10 mL). Trituration was performed using three glass Pasteur pipettes of decreasing diameters. For P30 datasets, enzymatic digestion and cell dissociation were carried out using the Worthington Papain Dissociation System, following the manufacturer’s instructions. Single-Nuclei Extraction: For nuclei isolation, the Hibernate™-E Medium was removed, and 500 µL of chilled 0.1X NP40 Lysis Buffer was added. Tissue was homogenized using a Pellet Pestle (15 strokes) and incubated on ice for 5 minutes. The suspension was pipette-mixed 10 times using a wide-bore pipette tip and incubated for an additional 10 minutes on ice. Following lysis, 500 µL of chilled wash buffer was added, and the mixture was pipette-mixed 5 times using a regular-bore pipette tip. The suspension was filtered through a 30 µm cell strainer into a 50 mL tube to remove debris. The filtered suspension was transferred to a 1.5 mL tube and centrifuged at 950 × g for 10 minutes at 4°C. The supernatant was carefully removed, and the nuclei pellet was retained for downstream analysis. (2)
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ENSMUSG00000076695 (1)
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Modelling Approach

Ordinary differential equation model (2)

Study type

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Lab affiliation

Molecular Physiology of the Synapse Laboratory Institut de Recerca Sant Pau (IR Sant Pau) C/Sant Quintí, 77-79 08041 Barcelona Spain (2)
2Department of Biological Sciences, Korea Advanced Institute for Science and Technology (KAIST) (1)
Biomolecular characterization unit, Center for Sustainable Resource Science, RIKEN (1)
CECAD Excellence Center & Center for Physiology, Medical Faculty, University of Cologne, Germany (1)
CECAD Excellence Center, University of Cologne, Germany, D-50931 Center for Physiology and Pathophysiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Germany, D-50931 (1)
Core Unit Proteomics, BIH at Charite and MDC, Robert Roessle Strasse 10, 13125 Berlin (1)
Department of Biological Sciences, Korea Advanced Institute for Science and Technology (KAIST) (1)
Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands (1)
ETH Zurich, D-HEST, Lab of Systems Neuroscience (1)
Institut du Fer a Moulin, Inserm-Sorbonne Université UMR-S 1270, Paris, France (1)
JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, College of Pharmacy, Jinan University, Guangzhou 510632, Guangdong, China. (1)
Johns Hopkins University (1)
Lab of Systems Neuroscience, Institute for Neuroscience, Department of Health Science and Technology, Swiss Federal Institute of Technology ETH, 8057 Zurich, Switzerland (1)
Ludwig-Maximilians; University Munich; Germany (1)
MPIs for Biophysics and Brain Research (1)
Max Planck Institute for Brain Research Max Planck Institute of Biophysics (1)
Max-Planck-Institute of Biochemistry (1)
Medical College of Xiamen University (1)
Quantitative Biosciences Institute (QBI), San Francisco, CA, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, USA;Gladstone Institute of Data Science and Biotechnology, J. David Gladstone Institutes, San Francisco, CA, USA (1)
Rappaport Faculty of Medicine and Network Biology Research Laboratories Fishbach Building, room 432 Technion City, Haifa 32000 Israel (1)
Room 6313, Academic building, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon (1)
Solomon H. Snyder Department of Neuroscience, Kavli Neuroscience Discovery Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA (1)
Tufts University School of Medicine (1)
UNIL – Department of Biomedical Sciences. Rue du Bugnon 7, 1005, Lausanne. (1)
Univ. Bordeaux, Bordeaux Proteome, Bordeaux, France (1)
University of California San Francisco (1)
Yale School of Medicine, Department of Neurolgy, Yale University (1)
Yale University, New Haven, CT 06511 (1)
Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA, USA (1)

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Transcription Factor Network Specifying Inhibitory versus Excitatory Neurons in the Dorsal Spinal Cord [RNA-Seq]

The proper balance of excitatory and inhibitory neurons is crucial to normal processing of somatosensory information in the dorsal spinal cord. Two neural basic helix-loop-helix transcription factors, Ascl1 and Ptf1a, are essential for generating the correct number and sub-type of neurons in multipl...

ORGANISM(S): Mus musculus

2014-06-13 | E-GEOD-55831 | biostudies-arrayexpress

Neuroinflammatory Stress Preferentially Impacts Synaptic MAPK Signaling and Mitochondria in Excitatory Neurons

In this study, we have applied cell type-specific in vivo biotinylation of proteins (CIBOP) to label Camk2a excitatory neuronal proteomes, and imposed differential centrifugation to prepare synaptosome-enriched fractions, followed by proteomic analysis of biotinylated neuronal proteins. This approac...

ORGANISM(S): Mus musculus (Mouse)

2026-04-13 | PXD068874 | Pride

Secretome protein enrichment with click sugars (SPECS) analysis on primary neurons cultured from embryos derived from pregnant mice treated with or without valproic acid

Autism Spectrum Disorder (ASD) is a developmental disorder characterized by impaired social communication and repetitive behaviors. In recent years, a pharmacological mouse model of ASD involving maternal administration of valproic acid (VPA) has become widely used. Newborn pups in this model show a...

ORGANISM(S): Mus Musculus (mouse)

2024-10-26 | PXD042099 | JPOST Repository

Neuregulin 3 promotes excitatory synapse formation on hippocampal interneurons.

Not available

S-EPMC6120667 | biostudies-literature

Sleep maintains excitatory synapse diversity in the cortex and hippocampus.

Not available

S-EPMC11359089 | biostudies-literature

Slitrks control excitatory and inhibitory synapse formation with LAR receptor protein tyrosine phosphatases.

Not available

S-EPMC3593915 | biostudies-literature

Presynaptic LRP4 promotes synapse number and function of excitatory CNS neurons.