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ProteomicsCD47 interactions with exportin-1 regulate targeting of m7G-capped RNAs to extracellular vesicles
CD47 is a marker of self and a signaling receptor for thrombospondin-1 that is also a membrane component of extracellular vesicles (EVs) released by various cell types. Previous studies identified CD47-dependent functional effects of EVs on target cells, mediated by delivery of their RNA contents, a...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-03-01 | MSV000086969 | MassIVE
ProteomicsXpo7 is a broad-spectrum exportin and a nuclear import receptor
Cargo molecules which exceed the passive diffusion limit of ~5nm require active translocation to cross the nuclear pore complex (NPC). Such a facilitated transport is achieved by specialized nuclear transport receptors (NTRs), which are classified according to their shuttling direction. Exportins bi...
ORGANISM(S): Mus musculus (Mouse) 
2018-05-07 | PXD008746 | Pride
Lc-msms Importin Exportin Nanobodies Npcs Erythropoiesis Rangtpase Mouse 
TranscriptomicsEffect of Exportin-5 expression on Mouse fibroblasts in cell cycle re-entry phase
To analyze the effect of Exportin-5 expression on the MEF cells in cell cycle re-entry phase, we have employed whole genome microarray expression profiling on the MEF cells in cell cycle re-entry phase with and without down regulation of Exportin-5 gene. Mouse MEF cells were transfected with 60nM of...
ORGANISM(S): Mus musculus 
2013-01-01 | E-GEOD-25498 | biostudies-arrayexpress
GenomicsCancer-associated exportin-6 upregulation inhibits the transcriptional repressive and anticancer effects of nuclear profilin-1
Cancer-associated exportin-6 upregulation inhibits the transcriptional repressive and anticancer effects of nuclear profilin-1
PRJNA603508 | ENA
GenomicsPseudouridine guides small RNA transport and inheritance via Exportin-t
Pseudouridine guides small RNA transport and inheritance via Exportin-t
PRJNA956931 | ENA
TranscriptomicsRe-evaluation of the roles of DROSHA, Exportin 5, and DICER in microRNA biogenesis
Biogenesis of canonical microRNAs (miRNAs) involves multiple steps: nuclear processing of primary miRNA (pri-miRNA) by DROSHA, nuclear export of precursor miRNA (pre-miRNA) by Exportin 5 (XPO5), and cytoplasmic processing of pre-miRNA by DICER. To gain a deeper understanding of the contribution of e...
ORGANISM(S): Homo sapiens 
2016-03-17 | E-GEOD-77989 | biostudies-arrayexpress
GenomicsExportin 1 inhibition prevents neuroendocrine transformation through SOX2 downregulation in lung and prostate cancers [ATAC-seq]
In lung and prostate adenocarcinomas, neuroendocrine (NE) transformation to an aggressive derivative resembling small cell lung cancer (SCLC) is associated with poor prognosis. We previously described dependency of SCLC on the nuclear transporter exportin 1. Here we explored the role of exportin 1 i...
ORGANISM(S): Homo sapiens 
2023-07-12 | GSE237071 | GEO
TranscriptomicsExportin 1 inhibition prevents neuroendocrine transformation through SOX2 downregulation in lung and prostate cancers [RNA-seq]
In lung and prostate adenocarcinomas, neuroendocrine (NE) transformation to an aggressive derivative resembling small cell lung cancer (SCLC) is associated with poor prognosis. We previously described dependency of SCLC on the nuclear transporter exportin 1. Here we explored the role of exportin 1 i...
ORGANISM(S): Homo sapiens 
2023-07-12 | GSE237072 | GEO
TranscriptomicsEffect of Exportin-5 expression on Mouse fibroblasts in cell cycle re-entry phase
To analyze the effect of Exportin-5 expression on the MEF cells in cell cycle re-entry phase, we have employed whole genome microarray expression profiling on the MEF cells in cell cycle re-entry phase with and without down regulation of Exportin-5 gene.
ORGANISM(S): Mus musculus 
2013-01-01 | GSE25498 | GEO
UnknownNucleocytoplasmic shuttling of JAZ, a new cargo protein for exportin-5.
Not available
S-EPMC444848 | biostudies-literature
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