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GenomicsCancer-associated exportin-6 upregulation inhibits the transcriptional repressive and anticancer effects of nuclear profilin-1
Cancer-associated exportin-6 upregulation inhibits the transcriptional repressive and anticancer effects of nuclear profilin-1
PRJNA603508 | ENA
TranscriptomicsCancer-associated exportin-6 upregulation inhibits the transcriptional repressive and anticancer effects of nuclear profilin-1
Aberrant expression of nuclear transporters and altered subcellular localization of their cargo proteins are increasingly recognized as drivers and therapeutic targets of cancer. Here, we report that exportin-6, a nuclear exporter specific for actin/profilin-1, is upregulated in a broad range of can...
ORGANISM(S): Homo sapiens 
2021-04-07 | GSE144372 | GEO
UnknownCancer-associated exportin-6 upregulation inhibits the transcriptionally repressive and anticancer effects of nuclear profilin-1.
Not available
S-EPMC8006859 | biostudies-literature
UnknownKey role of exportin 6 in exosome-mediated viral transmission from insect vectors to plants.
Not available
S-EPMC9457540 | biostudies-literature
UnknownExportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes.
Not available
S-EPMC275422 | biostudies-literature
UnknownLaminin-111 and the Level of Nuclear Actin Regulate Epithelial Quiescence via Exportin-6.
Not available
S-EPMC6663100 | biostudies-literature
ProteomicsRASSF1A IS REQUIRED FOR THE MAINTENANCE OF NUCLEAR ACTIN LEVELS
Nuclear actin participates in many essential cellular processes including gene transcription, chromatic remodelling and mRNA processing. Actin shuttles into and out the nucleus through the action of dedicated transport receptors importin-9 and exportin-6, but how this transport is regulated remains ...
ORGANISM(S): Homo sapiens (Human) 
2019-05-30 | PXD011517 | Pride
Nuclear actin Nucleocytoplasmic shuttling Mst2 Nuclear envelope Rassf1a Exportin-6 Nuclear export Srf Mrtf-a 
TranscriptomicsExportin 1 governs the immunosuppressive functions of tumor myeloid derived suppressor cells through ERK1/2 nuclear export
Myeloid derived suppressor cells (MDSCs) are a main driver of immunosuppression in tumors. Understanding the mechanisms that determine the development and immunosuppressive function of these cells could provide new therapeutic targets to improve anti-tumor immunity. Here, we discovered in preclinica...
ORGANISM(S): Mus musculus 
2024-06-30 | GSE269677 | GEO
UnknownMicroRNA (miR)-433 and miR-22 dysregulations induce histone-deacetylase-6 overexpression and ciliary loss in cholangiocarcinoma.
Not available
S-EPMC6078832 | biostudies-literature
UnknownRASSF1A is required for the maintenance of nuclear actin levels.
Not available
S-EPMC6694222 | biostudies-literature
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