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TranscriptomicsThe tumor suppressor Rassf1a prevents mouse liver tumorigenesis and regulates levels of the oncogenic kinase Tbk1 and of beta tubulin gene expression in the liver
The tumor suppressor gene RASSF1A (Ras association domain family protein 1A) coding for a microtubule stabilizing protein is epigenetically silenced in most human cancers. As a binding partner of the kinases MST1 and MST2, the mammalian orthologues of the Drosophila Hippo kinase, RASSF1A is a potent...
ORGANISM(S): Mus musculus 
2016-05-31 | E-GEOD-73911 | biostudies-arrayexpress
ProteomicsRASSF1A controls Tissue Stiffness and Cancer Stem-like Cells in Lung Adenocarcinoma
Lung cancer remains the leading cause of cancer-related death due to poor treatment responses and resistance arising from tumor heterogeneity. Here we show that adverse prognosis associated with epigenetic silencing of the tumour suppressor RASSF1A is due to increased deposition of extracellular mat...
ORGANISM(S): Homo sapiens (Human) 
2019-05-20 | PXD012694 | Pride
Cancer stem cells Hippo pathway Extracellular matrix. Stiffness 
ProteomicsRASSF1A IS REQUIRED FOR THE MAINTENANCE OF NUCLEAR ACTIN LEVELS
Nuclear actin participates in many essential cellular processes including gene transcription, chromatic remodelling and mRNA processing. Actin shuttles into and out the nucleus through the action of dedicated transport receptors importin-9 and exportin-6, but how this transport is regulated remains ...
ORGANISM(S): Homo sapiens (Human) 
2019-05-30 | PXD011517 | Pride
Nuclear actin Nucleocytoplasmic shuttling Mst2 Nuclear envelope Rassf1a Exportin-6 Nuclear export Srf Mrtf-a 
TranscriptomicsRASSF1A promotes its tumor-suppressive function via YAP1 target genes
The aim of the study was to determine the effect of the tumour suppressor RASSF1A in a stably induced YAP system, as both are members of the growth regulatory HIPPO pathway. YAP1 expression was induced by Doxycycline in stably transfected HEK293 cells. In addition the cells were transfected with RAS...
ORGANISM(S): Homo sapiens 
2017-05-15 | E-MTAB-4781 | biostudies-arrayexpress
GenomicsEffects of re-expressed RASSF1A on gene expression in rhabdoid tumor of the kidney cells.
Effects of re-expressed RASSF1A on gene expression in rhabdoid tumor of the kidney cells.
PRJNA719823 | ENA
TranscriptomicsModulator of Apoptosis 1 (MOAP-1) is a highly regulated tumor suppressor protein
Modulator of apoptosis 1 (MOAP-1) is a BH3-like protein that plays key roles in both the intrinsic and extrinsic modes of cell death or apoptosis. It is an integral partner to the tumor suppressor Ras association domain family 1A (RASSF1A) and functions to activate the Bcl-2 family pro-apoptotic pro...
ORGANISM(S): Homo sapiens 
2015-11-02 | E-GEOD-43990 | biostudies-arrayexpress
TranscriptomicsEffects of re-expressed RASSF1A on gene expression in rhabdoid tumor of the kidney cells.
Several groups reported the correlation between hypermethylation of RASSF1A and aggressiveness or a poor outcome in various pediatric tumors, including Wilms tumor. In addition, it is known that the overexpression of RASSF1A promotes apoptotic cell cycle arrest and reduces the tumorigenicity. In an ...
ORGANISM(S): Homo sapiens 
2024-04-05 | GSE171508 | GEO
GenomicsMUC1-C represses the RASSF1A tumor suppressor and activated Kras signaling in human carcinoma cells
MUC1-C represses the RASSF1A tumor suppressor and activated Kras signaling in human carcinoma cells
PRJNA510078 | ENA
GenomicsVhl and Rassf1a mutations cause DNA damage, chromosomal instability and induce gene expression changes characteristic of ccRCC [scRNA-seq]
Vhl and Rassf1a mutations cause DNA damage, chromosomal instability and induce gene expression changes characteristic of ccRCC [scRNA-seq]
PRJNA1177518 | ENA
TranscriptomicsMUC1-C represses the RASSF1A tumor suppressor and activated Kras signaling in human carcinoma cells
RASSF1A encodes a tumor suppressor that inhibits RAS’RAF’MEK’ERK signaling and is one of the most frequently inactivated genes in human cancers. MUC1-C is an oncogenic effector of the cancer cell epigenome that is overexpressed in diverse carcinomas. We show here that MUC1-C represses RASSF1A expres...
ORGANISM(S): Homo sapiens 
2019-05-27 | GSE123860 | GEO
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