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MetabolomicsF-actin dynamics couples sphingolipid metabolism to epithelial barrier integrity in chronic colitis
Intestinal barrier dysfunction is a hallmark of gastrointestinal disorders, including inflammatory bowel diseases (IBD). In IBD, the disruption of the gut barrier causes liquid loss and persistent immune response. Understanding the cellular events underlying epithelial barrier disruption during chro...
2026-04-01 | MTBLS14166 | MetaboLights
MetabolomicsTFAM loss induces nuclear actin assembly upon mDia2 malonylation to promote liver cancer metastasis
The mechanisms underlying cancer metastasis remain poorly understood. Here, we report that TFAM deficiency rapidly and stably induced spontaneous lung metastasis in mice with liver cancer. Interestingly, unexpected polymerization of nuclear actin was observed in TFAM-knockdown HCC cells when cytoske...
2022-06-23 | MTBLS4307 | MetaboLights
Proteomicsstudy of actin interactome in Alzheimers disease mouse model
Filamentous actin (F-actin) is one of the major cytoskeleton proteins present in dendritic spines and it is an essential component for defining dendritic spine morphology. We have shown that synaptosomal F-actin levels were significantly decreased in APP/PS1 mice as early as one month of age. The mo...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD050802 | Pride
F-actin loss Alzheimers disease Synapse 
GenomicsF-actin dynamics couples sphingolipid metabolism to epithelial barrier integrity in chronic colitis
F-actin dynamics couples sphingolipid metabolism to epithelial barrier integrity in chronic colitis
PRJNA1481546 | ENA
ProteomicsStructural basis of MICAL autoinhibition
MICAL proteins play a crucial role in cellular dynamics by binding and disassembling actin filaments, impacting processes like axon guidance, cytokinesis, and cell morphology. Their cellular activity is tightly controlled, as dysregulation can lead to detrimental effects on cellular morphology. Alth...
ORGANISM(S): Homo sapiens (Human) 
2024-10-30 | PXD057312 | Pride
F-actin depolymerization Actin Autoinhibition Rab Mical 
TranscriptomicsF-actin dynamics couples sphingolipid metabolism to epithelial barrier integrity in chronic colitis
Intestinal barrier dysfunction is a hallmark of gastrointestinal disorders, including inflammatory bowel diseases (IBD). In IBD, the disruption of the gut barrier causes fluid loss and persistent immune response. Understanding the cellular events underlying epithelial barrier disruption during chron...
ORGANISM(S): Mus musculus 
2026-06-24 | GSE336404 | GEO
ProteomicsPD-L1 intracellular interactions that necessitate the TSS motif within the cytoplasmic domain
Lymphatic endothelial cells (LEC) comprise lymphatic vessels that guide immune cells to lymph nodes (LN) and form the subcapsular sinus and cortical and medullary lymphatic structures of the LN. During an active immune response the lymphatics remodel to accommodate the influx of immune cells from th...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-06-01 | MSV000089579 | MassIVE
UnknownAfadin loss induces breast cancer metastasis through destabilisation of E-cadherin to F-actin linkage.
Not available
S-EPMC11985701 | biostudies-literature
GenomicsMyocardin-related transcription factors regulate F-actin organization during gastrulation and neural tube closure in Xenopus embryos
Myocardin-related transcription factors regulate F-actin organization during gastrulation and neural tube closure in Xenopus embryos
PRJNA1017869 | ENA
ProteomicsF-actin dynamics couples sphingolipid metabolism to epithelial barrier integrity in chronic colitis (proteomics)
Intestinal barrier dysfunction is a hallmark of gastrointestinal disorders, including inflammatory bowel diseases (IBD). In IBD, the disruption of the gut barrier causes liquid loss and persistent immune response. Understanding the cellular events underlying epithelial barrier disruption during chro...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-01 | PXD076239 | Pride
Cldn3 Ibd Actin 
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