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MetabolomicsLandscape of gut microbiota and metabolites and their interaction in comorbid heart failure and depressive symptoms: a random forest analysis study

Depression is an individual risk factor for poor prognosis in patients with heart failure (HF). Recent studies show that gut microbiota and metabolites have critical role in comorbid HF and depressive symptoms. We recruited 95 subjects including 35 HF patients with depressive symptoms (HF-DS), 36...

2023-10-23 | MTBLS8183 | MetaboLights
UnknownThe combination of the opioid glycopeptide MMP-2200 and a NMDA receptor antagonist reduced l-DOPA-induced dyskinesia and MMP-2200 by itself reduced dopamine receptor 2-like agonist-induced dyskinesia.
Not available
S-EPMC6309213 | biostudies-literature
UnknownA geo-enabled digital tool for microplanning and delivery of indoor residual spray in Zambia: A case study, 2016-2020.
Not available
S-EPMC12633927 | biostudies-literature
Transcriptomicsjejunal Peyer’s patch (JPP) gene expression relative to jejunal mesenteric lymph node (j-MLN) gene expression.
Although immune mechanisms have been described for Peyer’s patch function, in discriminating food nutrients and commensal microflora from pathogenic challenge, an understanding of gene expression patterns associated with normal intestinal homeostasis is lacking. The effects of commensal bacterial co...
ORGANISM(S): Sus scrofa 
2004-11-04 | E-GEOD-1913 | biostudies-arrayexpress
UnknownA Phase 2, Double-Blind, Placebo-Controlled Randomized Trial Assessing the Efficacy of ABT-436, a Novel V1b Receptor Antagonist, for Alcohol Dependence.
Not available
S-EPMC5506792 | biostudies-literature
ProteomicsTrnp1 is a novel regulator of several nuclear membrane-less compartments
TMF1-regulated nuclear protein 1 (Trnp1) has been shown to exert potent roles in neural development affecting neural stem cell self-renewal and brain folding, but its molecular function in the nucleus is still unknown. Here we show that Trnp1 is a low complexity protein with the capacity to phase se...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-25 | PXD018350 | Pride
Trnp1 Nucleoli Phase transition Nuclear speckles Heterochromatin 
ProteomicsEpigenetic homogeneity in histone methylation underlies sperm programming for embryonic transcription
Sperm contributes genetic and epigenetic information to the embryo to efficiently support development. However, the mechanism underlying such developmental competence remains elusive. Here, we investigated whether all sperm cells have a common epigenetic configuration that primes transcriptional pro...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2020-05-29 | PXD012853 | Pride
Epigenetics Programming Sperm Ice-chip Lc-ms/ms 
UnknownMicrobiota and metabolite-based prediction tool for colonic polyposis with and without a known genetic driver.
Not available
S-EPMC11913376 | biostudies-literature
UnknownAlpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity.
Not available
S-EPMC6531426 | biostudies-literature
UnknownBehavioral interventions motivate action to address climate change.
Not available
S-EPMC12107114 | biostudies-literature
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