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ProteomicsiTRAQ-based analysis of muscle mitochondria isolated from LONP1-mKO mice
This experiment was conducted to identify the mitochondrial protein changes in the presence and absence of LONP1 in skeletal muscle. The following abstract from the submitted manuscript describes the major findings of this work.Disuse-associated loss of muscle LONP1 impairs mitochondrial quality and...
ORGANISM(S): Mus musculus (Mouse) 
2022-01-05 | PXD029722 | Pride
Mouse Skeletal muscle 
ProteomicsIgA transcytosis and tumor antigen recognition govern anti-tumor immunity in ovarian cancer
Although most ovarian cancers show prognostically relevant activated T-cell infiltrates, response rates to immune checkpoint inhibitors are very modest4. Memory B-cell and plasma cell infiltrates have been associated with better outcome in ovarian cancer, but the nature and functional relevance of t...
ORGANISM(S): Homo sapiens (Human) 
2020-12-01 | PXD018079 | Pride
Ovarian cancer Prm Immunoglobulin a Transcytosis Lc-ms/ms Immunotherapy 
ProteomicsDIA-Based Quantitative Proteomic Analysis of Early and Late Endosomes in A549 Cells Following Amphotericin B Pretreatment and Influenza A Virus Infection
Amphotericin B (AmB) is a polyene macrolide antifungal agent that binds to ergosterol, disrupting fungal membranes through lipid interactions. However, its effects on host cell protein composition remain unclear. In this study, A549 cells were pretreated with AmB prior to infection with the influenz...
ORGANISM(S): Homo sapiens (Human) 
2026-02-02 | PXD064637 | Pride
Amphotericin b  influenza a virus  endosome  dia proteomics 
UnknownLow temperature and high humidity affect dynamics of chlorophyll biosynthesis and secondary metabolites in Cucumber.
Not available
S-EPMC11441134 | biostudies-literature
MetabolomicsAlterations in the Gut Microbiota and Metabolomics of Seafarers after a Six-Month Sea Voyage

Maintaining the health of seafarers is a difficult task during long-term voyages. Little is known about the corresponding changes in the gut microbiome-host interaction. This study recruited 30 seafarers undertaking a 6-month voyage and analyzed their gut microbiota using 16S rRNA gene sequencing...

2022-09-29 | MTBLS5335 | MetaboLights
ProteomicsHoneybee brain neuropeptides LC-MSMS
To explore brain neuropeptidic functions in behavioral regulation, a label-free quantitative strategy was employed to compare neuropeptidomic variations between behavioral phenotypes (nurse bees, nectar foragers, and pollen foragers) and the two honeybee species (Apis mellifera ligustica and Apis ce...
ORGANISM(S): Apis mellifera (Honeybee) 
2021-09-09 | PXD018713 | Pride
Lc-msms Brain Honeybee Neruopeptide 
UnknownBand structural and absorption characteristics of antimonene/bismuthene monolayer heterojunction calculated by first-principles.
Not available
S-EPMC9388903 | biostudies-literature
GenomicsDiscrete Functions of Rev-erba Couple Metabolism to the Clock [HTS]
Circadian and metabolic physiology are intricately intertwined, as illustrated by Rev-erb , a transcription factor (TF) that functions both as a core repressive component of the cell autonomous clock and as a regulator of metabolic genes. Here we show that Rev-erb modulates the clock and metabolis...
ORGANISM(S): Mus musculus 
2015-06-16 | E-GEOD-67962 | biostudies-arrayexpress
ProteomicsUnc-51 Like Kinase 3 (ULK3) is essential for autophagy and cell survival in multiple myeloma
Despite the availability of effective therapies such as proteasome inhibitors, multiple myeloma (MM) patients relapse with refractory disease. To identify new therapeutic targets, we assessed RNA sequencing data from CD138+ MM patient cells (n = 813) across disease stages and found that an autophagy...
ORGANISM(S): Homo sapiens (Human) 
2026-05-27 | PXD067362 | Pride
Autophagy Ulk3 Interactome Multiple myeloma 
ProteomicsQuantitative proteomic analysis of global protein acetylation in PRRSV infected pulmonary alveolar macrophages
Porcine reproductive and respiratory syndrome (PRRS), which caused by the porcine reproductive and respiratory syndrome virus (PRRSV), is a serious viral disease affecting global swine industry. At present, PRRSV vaccines fail to prevent this disease. Consequently, new antiviral strategies to compen...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2020-12-11 | PXD016927 | Pride
Porcine reproductive and respiratory syndrome  tandem mass tag label lc-ms  post-translational modification  acetylation. 
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