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MetabolomicsIncreased adipose tissue Fas alters gut microbiota to aggravate colitis in obesity— Adipose Fas aggravates colitis via gut microbiota in obesity
Obesity is increasingly recognized as a factor that may exacerbate inflammatory bowel disease (IBD), yet the underlying mechanisms remain poorly understood. This study investigates whether upregulated Fas (CD95) expression in adipose tissue contributes to obesity-associated aggravation of colitis, w...
2026-09-03 | MTBLS15480 | MetaboLights
TranscriptomicsRegulation of FAS Exon Definition and Apoptosis by the Ewing Sarcoma Protein
The EwingM-bM-^@M-^Ys sarcoma protein EWS belongs to the TET family (FUS/TLS, EWS, TAF15) of RNA and DNA binding proteins, implicated in DNA transcription, pre-mRNA splicing and maintenance of genomic integrity. Translocations of these genes are characteristic of particular neoplasias, including Ewi...
ORGANISM(S): Homo sapiens 
2014-05-21 | E-GEOD-48065 | biostudies-arrayexpress
ProteomicsCMTM6 suppresses cell-surface expression of death receptor FAS in mice but not in humans - mouse FAS interactome
The transmembrane protein CMTM6 promotes plasma membrane expression of immune checkpoint PD-L1, an important suppressor of anti-tumor immunity. Targeting of CMTM6 was proposed as a strategy to decrease surface PD-L1 and trigger cytotoxicity against tumors. In accord, ablation of CMTM6 in mouse cance...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-16 | PXD070298 | Pride
Fas Cmtm6 Cd95 
ModelsWebb2002 - Fas/FasL mediated tumor T-cell interaction
Webb2002 - Fas/FasL mediated tumor T-cell interaction This deterministic model of immunological surveillance involving tumour cell–T-lymphocyte interaction, cell surface expression of Fas/FasL, and their secreted soluble forms. This model is described in the article: Cells behaving badly: ...
2024-09-02 | BIOMD0000000661 | BioModels
TranscriptomicsTranscription profiling of human atherosclerotic lesion SMC cells resistant and sensitive to TGF and Fas ligation by CH11 antibody
Comparison of SMC resistant and sensitive to TGF and Fas ligation by CH11 antibody
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-2522 | biostudies-arrayexpress
ProteomicsA survival mechanism controlled by cadherins and Dlg1 polarity complex inhibits Fas cell death receptor signaling
A fine regulation of epithelia cell death is required to maintain tissue integrity and homeostasis. At a cellular level, this life and death decision is controlled by environmental stimuli including death receptors activation. Here, we show that establishment of cell polarity and AJ formation contro...
ORGANISM(S): Homo sapiens (Human) 
2018-09-20 | PXD009659 | Pride
Human Lc-msms Cell polarity Pdz Epithelia Death receptor Cell death 
TranscriptomicsIncreased Cell Surface Fas Expression is Necessary to Sensitize Lung Fibroblasts to Fas Ligation-Induced Apoptosis: Implications for Fibroblast Accumulation in Idiopathic Pulmonary Fibrosis.
Idiopathic pulmonary fibrosis (IPF) is associated with the accumulation of collagen-secreting fibroblasts and myofibroblasts in the lung parenchyma. Many mechanisms contribute to their accumulation, including resistance to apoptosis. In previous work, we showed that exposure to the pro-inflammatory ...
ORGANISM(S): Homo sapiens 
2011-01-13 | E-GEOD-26594 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of in vivo-derived CMS4-met cells and the in vitro-derived CMS4.sel cells using CMS4 cells as a reference sample
The CMS4 sarcoma, kindly provided by A. DeLeo (University of Pittsburgh, Pittsburgh, PA), is a solid tumor of BALB/c (H-2d) origin, which grows aggressively in naive, syngeneic hosts following a s.c. transplant. Although the parental tumor cell line forms few metastatic foci in the lungs following i...
ORGANISM(S): Mus musculus 
2005-05-08 | E-MEXP-286 | biostudies-arrayexpress
ProteomicsARID1A mutations protect follicular lymphoma from FAS-dependent immune surveillance by reducing RUNX3/ETS1-driven FAS-expression
The cell death receptor FAS and its ligand (FASLG) play crucial roles in the selection of B cells during the germinal center (GC) reaction. Failure to eliminate potentially harmful B cells via FAS can lead to lymphoproliferation and the development of B cell malignancies. The classic form of follicu...
ORGANISM(S): Homo Sapiens 
PXD041408 | panorama
ProteomicsCMTM6 suppresses cell-surface expression of death receptor FAS in mice but not in humans - mouse CMTM3-8 interactome
The transmembrane protein CMTM6 promotes plasma membrane expression of immune checkpoint PD-L1, an important suppressor of anti-tumor immunity. Targeting of CMTM6 was proposed as a strategy to decrease surface PD-L1 and trigger cytotoxicity against tumors. In accord, ablation of CMTM6 in mouse cance...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-16 | PXD070246 | Pride
Cmtm3 Fas Cmtm8 Cmtm7 Cmtm6 Cmtm5 Cmtm4 Cd95 
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