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The role of CMTM3 in a sepsis mouse model
Sepsis is a life-threatening condition characterized by an imbalanced immune response to infection, leading to multiple organ dysfunction. It has a high incidence and mortality rate. CMTM3 is a member of the CKLF-like MARVEL transmembrane domain (CMTM) gene superfamily, and it is widely expressed in...
ORGANISM(S): Mus musculus 
2024-12-18 | GSE247363 | GEO
The transmembrane protein CMTM6 promotes plasma membrane expression of immune checkpoint PD-L1, an important suppressor of anti-tumor immunity. Targeting of CMTM6 was proposed as a strategy to decrease surface PD-L1 and trigger cytotoxicity against tumors. In accord, ablation of CMTM6 in mouse cance...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-16 | PXD070246 | Pride
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