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TranscriptomicsCMTM6 drives cisplatin resistance by regulating AKT mediated Wnt signaling
The RNA-seq library preparation was performed for H357 CisR Nt Sh and H357 CisR CMTM6 shRNA treated with vehicle control (UT) and cisplatin (10 μM) (CisT) for 24 h. We have included two independent biological replicates to identify the CMTM6 downregulation mediated global transcriptome changes. For ...
ORGANISM(S): Homo sapiens 
2021-02-08 | E-MTAB-9424 | biostudies-arrayexpress
ProteomicsCMTM6 suppresses cell-surface expression of death receptor FAS in mice but not in humans - human CMTM6 interactome
The transmembrane protein CMTM6 promotes plasma membrane expression of immune checkpoint PD-L1, an important suppressor of anti-tumor immunity. Targeting of CMTM6 was proposed as a strategy to decrease surface PD-L1 and trigger cytotoxicity against tumors. In accord, ablation of CMTM6 in mouse cance...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-16 | PXD070359 | Pride
Cd58 Cmtm6 
ProteomicsCMTM6 suppresses cell-surface expression of death receptor FAS in mice but not in humans - mouse FAS interactome
The transmembrane protein CMTM6 promotes plasma membrane expression of immune checkpoint PD-L1, an important suppressor of anti-tumor immunity. Targeting of CMTM6 was proposed as a strategy to decrease surface PD-L1 and trigger cytotoxicity against tumors. In accord, ablation of CMTM6 in mouse cance...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-16 | PXD070298 | Pride
Fas Cmtm6 Cd95 
ProteomicsCMTM6 suppresses cell-surface expression of death receptor FAS in mice but not in humans - mouse CMTM3-8 interactome
The transmembrane protein CMTM6 promotes plasma membrane expression of immune checkpoint PD-L1, an important suppressor of anti-tumor immunity. Targeting of CMTM6 was proposed as a strategy to decrease surface PD-L1 and trigger cytotoxicity against tumors. In accord, ablation of CMTM6 in mouse cance...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-16 | PXD070246 | Pride
Cmtm3 Fas Cmtm8 Cmtm7 Cmtm6 Cmtm5 Cmtm4 Cd95 
GenomicsCMTM6 drives cisplatin resistance by regulating AKT mediated Wnt signaling
CMTM6 drives cisplatin resistance by regulating AKT mediated Wnt signaling
PRJEB39795 | ENA
GenomicsRNA sequencing to compare gene expression in control and CMTM6 knockdown colon cancer cells
RNA sequencing to compare gene expression in control and CMTM6 knockdown colon cancer cells
PRJNA1061209 | ENA
TranscriptomicsRNA sequencing to compare gene expression in control and CMTM6 knockdown colon cancer cells
Human colorectal cancer cell line HCT116 was purchased from ATCC (Manassas, VA, USA). They were transduced with lentiviruses encoding control shRNA or CMTM6 shRNA. Cells were collected for RNA isolation and RNA sequencing. The goal of this study is to identify genes transcriptionally regulated by CM...
ORGANISM(S): Homo sapiens 
2025-06-11 | GSE252571 | GEO
UnknownConstruction of stable membranal CMTM6-PD-L1 full-length complex to evaluate the PD-1/PD-L1-CMTM6 interaction and develop anti-tumor anti-CMTM6 nanobody.
Not available
S-EPMC10104848 | biostudies-literature
ProteomicsThe CD58:CD2 axis is co-regulated with PD-L1 via CMTM6 and shapes anti-tumor immunity
The cell-autonomous balance of immune-inhibitory and -stimulatory signals is a critical process in cancer immune evasion. Using patient-derived co-cultures, humanized mouse models, and single cell RNA-sequencing of patient melanomas biopsied before and on immune checkpoint blockade, we find that int...
ORGANISM(S): Homo sapiens (Human) 
2023-07-06 | PXD039710 | Pride
Human Cd58 Melanoma 
UnknownCMTM6 overexpression confers trastuzumab resistance in HER2-positive breast cancer.
Not available
S-EPMC9830830 | biostudies-literature
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