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GenomicsFASTKD5 processes mitochondrial pre-mRNAs at non-canonical cleavage sites
FASTKD5 processes mitochondrial pre-mRNAs at non-canonical cleavage sites
PRJNA1230219 | ENA
OtherFASTKD5 processes mitochondrial pre-mRNAs at non-canonical cleavage sites
The first post-transcriptional step in mammalian mitochondrial gene expression, required for the synthesis of the 13 polypeptides encoded in mtDNA, is endonucleolytic cleavage of the primary polycistronic transcripts. Excision of the mtDNA-encoded tRNAs releases most mature RNAs; however, processing...
ORGANISM(S): Homo sapiens 
2025-06-29 | GSE290841 | GEO
UnknownFASTKD5 processes mitochondrial pre-mRNAs at noncanonical cleavage sites.
Not available
S-EPMC12242768 | biostudies-literature
UnknownBi-allelic mutations in FASTKD5 are associated with cytochrome c oxidase deficiency and early- to late-onset Leigh syndrome.
Not available
S-EPMC12256832 | biostudies-literature
ProteomicsThe FASTK family proteins are master regulators in mitochondrial RNA processing
The FASTK family proteins are emerging key post-transcriptional regulators in mitochondrial gene expression. In attempts to uncover their molecular functions, we carried out BioID experiments to identify proteins interacting with FASTKD4 and FASTKD5. Our data suggest that both proteins have similar ...
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD020993 | Pride
Human Fastkd4 Fastkd5 Bioid 
ProteomicsMulti-omics analyses reveal that HIV-1 alters CD4 T cell immunometabolism to fuel virus replication
Human Immunodeficiency Virus type-1 (HIV-1)-infected individuals show metabolic alterations of CD4 T cells through unclear mechanisms with undefined consequences. We analyzed the transcriptome of CD4 T cells from HIV-1 patients and revealed that elevated oxidative phosphorylation (OXPHOS) pathway i...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD023565 | Pride
Hiv-1 Cd4 t cell Virus replication Nlrx1 Fastkd5 Oxidative phosphorylation 
UnknownSystematic Analysis of FASTK Gene Family Alterations in Cancer.
Not available
S-EPMC8583194 | biostudies-literature
UnknownThe FASTK family proteins fine-tune mitochondrial RNA processing.
Not available
S-EPMC8601606 | biostudies-literature
UnknownMulti-omics Analysis of Prognostic Significance and Immune Infiltration of FASTK Family Members in Kidney Renal Clear Cell Carcinoma.
Not available
S-EPMC10683404 | biostudies-literature
OtherA kinetic dichotomy between mitochondrial and nuclear gene expression processes
Oxidative phosphorylation (OXPHOS) complexes, encoded by both mitochondrial and nuclear DNA, are essential producers of cellular ATP, but how nuclear and mitochondrial gene expression steps are coordinated to achieve balanced OXPHOS subunit biogenesis remains unresolved. Here, we present a parallel ...
ORGANISM(S): Homo sapiens 
2024-03-18 | GSE224163 | GEO
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