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ProteomicsThe ubiquitin ligase Triad1 influences myeloid leukemogenesis by regulating the integrated stress response
Increased expression of a set of homeodomain transcription factors, including HoxA10A, characterizes an adverse prognosis subtype of acute myeloid leukemia (AML). This increase in Hox expression may be found in AML with KMT2A or MYST3/CREBBP gene rearrangements, or with normal cytogenetics. Previous...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD060787 | Pride
Innate immunity Leukemia Ubiquitination E3 ubiquitin ligase Gene expression 
ProteomicsIdentification of Cdc14 phopho-targets in response to DNA damage
We have previously shown that the Cdc14 phosphatase is essential for an efficient repair of a DNA lesion, however we still missing how the phosphatase exerts this molecular functions and what are its targets during the repair process. To identify Cdc14 phospho-targets in response to DNA damage, we p...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2016-12-22 | PXD004966 | Pride
Dna damage Saccharomyces cerevisiae Cdc14 
ProteomicsInvestigating macrophage multinucleation by LC-MS/MS
Macrophage multinucleation (MM) is essential for various biological processes such as osteoclast-mediated bone resorption and multinucleated giant cell-associated inflammatory reactions. Here we study the molecular pathways underlying multinucleation in the rat through an integrative approach combin...
ORGANISM(S): Rattus norvegicus (Rat) 
2016-07-06 | PXD001269 | Pride
Rat Protein Wky Macrophage 
ProteomicsInvestigation of LARP1 regulated cellular pathways in acute myeloid leukemia
La-related protein 1 (LARP1) is an RNA-binding protein and downstream effector of mTOR and CDK9 signaling that regulates the translation of 5’-TOP mRNAs. While elevated LARP1 expression has been linked to poor prognosis in acute myeloid leukemia (AML), its mechanistic role remains unclear. Using CRI...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD064460 | Pride
Larp1 Acute myeloid leukemia 
ProteomicsLocal depletion of proteoglycans mediates cartilage tissue repair in an ex vivo integration model
Successfully replacing damaged cartilage with tissue-engineered constructs requires integration with the host tissue and could benefit from leveraging the native tissue's intrinsic healing capacity; however, efforts are limited by a poor understanding of how cartilage repairs minor defects. Here, we...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2022-07-18 | PXD035246 | Pride
Proteoglycan depletion Cartilage repair Catabolic enzyme Tissue engineering 
ProteomicscGAS Senses Translation Stress Through Direct Binding to Ribosomes
The cGAS-STING pathway, a central component of the innate immune system, senses cytosolic DNA and induces interferon-stimulated genes (ISGs) to mediate inflammation. Here we report the unexpected discovery that cGAS senses dysfunctional protein production. Purified ribosomes interact with and stimul...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD019359 | Pride
Ribosomes Ascc Human Cgas 
ProteomicsHuman DDI2 is a ubiquitin-directed endo-protease
The Ddi1/DDI2 proteins are classified as ubiquitin shuttling factors and are implicated in a wide range of cellular functions. In addition to ubiquitin-binding and ubiquitin-like domains, these proteins contain a conserved region with similarity to retroviral proteases, but whether and how they func...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD018215 | Pride
Human Silac Ddi2 Ubiquitin 
ProteomicsNascent RNA antagonises the interaction of regulatory proteins with chromatin
A number of transcriptional and chromatin regulatory proteins have been reported to be recruited to chromatin by specific regulatory RNAs. Whether RNA has a more general role in the interaction of proteins with chromatin is unknown. We used proteomics methods to determine the global impact of nascen...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-15 | PXD018706 | Pride
Rna Regulatory proteins Chromatin 
TranscriptomicsTranscruption profiling of human cerebellum, frontal cortex [BA4, BA9] and caudate nucleus HD tissue experiment
Post mortem human brain tissue comparison between HD patients and controls from 3 brain regions - cerebellum, frontal cortex [BA4, BA9] and caudate nucleus. Gene expression analysed using linear models from LIMMA package in Bioconductor suite. Experiment Overall Design: Large sample sizes were used...
ORGANISM(S): Homo sapiens 
2009-09-12 | E-GEOD-3790 | biostudies-arrayexpress
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