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ProteomicsProteome profiling of trophoblasts reveals calcium involvement in syncytialisation and hormone production
Endocrine hormones of the placenta are essential for the maintenance of pregnancy, and disturbances in trophoblast integrity are associated with pregnancy complications. Here, we combine human trophoblast cell cultures, hormone assays, antibody-based detection methods and high-resolution mass spectr...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054348 | Pride
Syncytialisation Trophoblast Placenta Calcium Hormone synthesis Proteome 
ProteomicsTripartite interactions of PKA catalytic subunit and C-terminal domains of cardiac Ca2+ channel may modulate its β-adrenergic regulation
The β-adrenergic augmentation of cardiac contraction, by increasing the conductivity of L-type voltage-gated CaV1.2 channels, is of great physiological and pathophysiological importance. Stimulation of β-adrenergic receptors (βAR) activates protein kinase A (PKA) through separation of regulatory (PK...
ORGANISM(S): Homo sapiens (Human) 
2024-11-22 | PXD057841 | Pride
Calcium channel  protein‐protein interaction  adrenergic regulation  cardiac  protein kinase a (pka)  heterologous expression 
ProteomicsT-cell derived exosomes released from Multi-Core Granules exhibit potent caspase 3 mediated tumor suppressive activity ( Part II)
Small extracellular vesicles (sEV) derived from cytotoxic T lymphocytes (CTLs) are emerging as potential mediators of antitumor immunity, yet their subcellular origins and functional properties remain incompletely defined. In this study, we investigated the intracellular routes and cytotoxic potenti...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-23 | PXD070419 | Pride
Tetraspanins 10x-expansion Munc13-4 Extracellular vesicles Primary cells Cd8+ t-cells Immunological synapse Multivesicular bodies 
ProteomicsThe intracellular localization and the ionic permeation of TRPV6 triggers chronic pancreatitis, skeletal dysplasia and is connected to mucolipidosis type II
Heterozygous TRPV6 mutations, which reduce significantly the Ca2+-permeability of the channel, lead to chronic pancreatitis and, if both TRPV6-alleles are affected, to skeletal dysplasia with neonatal transient hyperparathyroidism (TNHP) of newborns. We show that TRPV6 channels are localized in intr...
ORGANISM(S): Homo sapiens (Human) 
2026-02-02 | PXD065752 | Pride
Transient receptor potential I-cell disease Trpv6 Mucolipidosis type ii Skeletal dysplasia Calcium channel Gnptab Chronic pancreatitis Mannose-6-phosphate 
ProteomicsThe intracellular localization and the ionic permeation of TRPV6 triggers chronic pancreatitis, skeletal dysplasia and is connected to mucolipidosis type II (data part II)
Heterozygous TRPV6 mutations, which reduce significantly the Ca2+-permeability of the channel, lead to chronic pancreatitis and, if both TRPV6-alleles are affected, to skeletal dysplasia with neonatal transient hyperparathyroidism (TNHP) of newborns. We show that TRPV6 channels are localized in intr...
ORGANISM(S): Homo sapiens (Human) 
2026-02-02 | PXD065789 | Pride
Transient receptor potential I-cell disease Trpv6 Mucolipidosis type ii Skeletal dysplasia Calcium channel Gnptab Chronic pancreatitis Mannose-6-phosphate 
ProteomicsIs the proteomic composition of the salivary pellicle dependent on the substrate material? PII
This study aimed at characterizing the individual proteomic composition of the 3-min pellicle formed on bovine enamel and six restorative materials. Substrate material-specific adsorption patterns were analyzed by comparing the proteomic profiles of the 3-min pellicle with the corresponding saliva
ORGANISM(S): Homo sapiens (Human) 
2022-04-13 | PXD031449 | Pride
Nano-lc-hr-ms/ms Salivary protein enrichment/depletion Dental materials Quantitative proteomic comparisons Individual 3-min pellicle proteome 
ProteomicsIs the proteomic composition of the salivary pellicle dependent on the substrate material? PV
This study aimed at characterizing the individual proteomic composition of the 3-min pellicle formed on bovine enamel and six restorative materials. Substrate material-specific adsorption patterns were analyzed by comparing the proteomic profiles of the 3-min pellicle with the corresponding saliva.
ORGANISM(S): Homo sapiens (Human) 
2022-04-11 | PXD031452 | Pride
Nano-lc-hr-ms/ms Salivary protein enrichment/depletion Dental materials Quantitative proteomic comparisons Individual 3-min pellicle proteome 
ProteomicsIs the proteomic composition of the salivary pellicle dependent on the substrate material? PIII
This study aimed at characterizing the individual proteomic composition of the 3-min pellicle formed on bovine enamel and six restorative materials. Substrate material-specific adsorption patterns were analyzed by comparing the proteomic profiles of the 3-min pellicle with the corresponding saliva.
ORGANISM(S): Homo sapiens (Human) 
2022-04-11 | PXD031454 | Pride
Nano-lc-hr-ms/ms Salivary protein enrichment/depletion Dental materials Quantitative proteomic comparisons Individual 3-min pellicle proteome 
ProteomicsIs the proteomic composition of the salivary pellicle dependent on the substrate material? PIV
This study aimed at characterizing the individual proteomic composition of the 3-min pellicle formed on bovine enamel and six restorative materials. Substrate material-specific adsorption patterns were analyzed by comparing the proteomic profiles of the 3-min pellicle with the corresponding saliva.
ORGANISM(S): Homo sapiens (Human) 
2022-04-13 | PXD031418 | Pride
Nano-lc-hr-ms/ms Salivary protein enrichment/depletion Dental materials Quantitative proteomic comparisons Individual 3-min pellicle proteome 
ProteomicsIs the proteomic composition of the salivary pellicle dependent on the substrate material?
Dental materials, individual 3-min pellicle proteome, nano-LC-HR-MS/MS, quantitative proteomic comparisons, salivary protein enrichment/depletion
ORGANISM(S): Homo sapiens (Human) 
2022-04-13 | PXD031428 | Pride
Nano-lc-hr-ms/ms Salivary protein enrichment/depletion Dental materials Quantitative proteomic comparisons Individual 3-min pellicle proteome 
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