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ProteomicsTissue expression of N-terminal proteoforms.
To evaluate the expression of N-terminal proteoforms (protein isoforms with different N-terminus expressed from the same gene) in healthy human tissues, we re-analyzed public proteomics data of the draft map of the human proteome developed by the Pandey group (PRIDE project PXD000561). Using ionbot ...
ORGANISM(S): Homo sapiens (Human) 
2023-06-12 | PXD039339 | Pride
Proteoforms Healthy tissue Human 
ProteomicsThe dynamic rRNA ribomethylome drives stemness in acute myeloid leukemia
Eukaryotic ribosomal RNA carries diverse posttranscriptional modifications, among which the evolutionarily conserved 2’-O-methylation (2’-O-Me) occurs at more than 100 sites and is essential for ribosome biogenesis. Plasticity of 2´-O-Me in ribosomes and its functional consequences in human disease ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD029527 | Pride
Fbl Leukemia Nascent chain proteomics Rrna Aha 2’-o-methylation Aml 
ProteomicseIF1 modulates the recognition of sub-optimal translation start sites and steers gene expression control mediated by uORFs.
Alternative translation initiation mechanisms such as leaky scanning and re-initiation potentiate the polycistronic nature of transcripts. By allowing for reprogrammed translation, these mechanisms can mediate biological responses to stress stimuli. We combined proteomics with ribosome profiling and...
ORGANISM(S): Homo sapiens (Human) 
2017-09-13 | PXD004980 | Pride
Q-exactive hf Alternative translation initiation Human Label-free shotgun proteomics Eif1 Eif1b 
ProteomicsCheck of selected NTR peptide spectra by comparison with synthetic peptides
Ribosome profiling has revealed translation outside of canonical coding sequences (CDSs) including translation of short upstream ORFs, long non-coding RNAs, overlapping ORFs, ORFs in UTRs or ORFs in alternative reading frames. Studies combining mass spectrometry, ribosome profiling and CRISPR-based ...
ORGANISM(S): Homo Sapiens 
2022-08-02 | PXD030285 | panorama
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