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GenomicsDNAseq of human Ewing cell line - CADO-ES1
Ewings Sarcoma (ES) belongs to the group of bone cancers defined by the existence of a certain EWS-ETS fusion gene. In this study we use the model cell line CADO-ES1 (EWSR1-ERG fusion gene) to characterize the genomic structure in respect to CNV and fusion gene events.
ORGANISM(S): Homo sapiens 
2017-10-02 | E-MTAB-6111 | biostudies-arrayexpress
TranscriptomicsRNAseq of human Ewing, MSC, fibroblast cell lines - A side population of Ewing cells exhibits stem cell properties
Ewings Sarcoma (ES) belongs to the group of bone cancers defined by the existence of a certain EWS-ETS fusion gene. In this study we use the model cell line CADO-ES1 (EWSR1-ERG fusion gene) to characterize the tumor biology of a versatile ES side-population (SP). We aim to compare SP- and non-SP-cel...
ORGANISM(S): Homo sapiens 
2017-10-31 | E-MTAB-6067 | biostudies-arrayexpress
MetabolomicsMetabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS
As metabolic rewiring is crucial for cancer cell proliferation, metabolic phenotyping of patient-derived organoids is desirable to identify drug-induced changes and trace metabolic vulnerabilities of tumor subtypes. We established a novel protocol for metabolomic and lipidomic profiling of colorecta...
2021-10-12 | MTBLS2130 | MetaboLights
UnknownSubstituted 4-methylcoumarin inhibitors of SLC26A3 (DRA) for treatment of constipation and hyperoxaluria.
Not available
S-EPMC11110725 | biostudies-literature
TranscriptomicsOxidative burden and mitochondrial dysfunction in a mouse model of Rett syndrome
To identify the detailed molecular causes of the mitochondrial dysfunction, oxidative burden and more vulnerable redox balance in Rett mouse hippocampus, we screened for differential gene expression in the hippocampal CA1 subfield of adult male mice. A whole mouse genome microarray was performed to ...
ORGANISM(S): Mus musculus 
2012-08-31 | E-GEOD-32870 | biostudies-arrayexpress
ProteomicsProteogenomics reveals two distinct biological pilocytic astrocytoma subgroups
Pilocytic astrocytoma (PA) is the most common pediatric brain tumor and driven by aberrant MAPK signaling, typically mediated by BRAF alterations. While five-year overall survival rates exceed 95%, tumor recurrence constitutes a major clinical challenge in incompletely resected tumors despite chemot...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD035773 | Pride
Lc-msms Pilocytic astrocytoma Brain tumour 
ProteomicsProteomes of Wenzhouxiangella isolate grown on three substrates
A new haloalkaliphilic species of Wenzhouxiangella, strain AB-CW3 was isolated from a system of alkaline soda lakes in the Kulunda Steppe. Its complete, circular genome was assembled from combined nanopore and illumina sequencing and its proteome was determined for three different experimental condi...
ORGANISM(S): Wenzhouxiangellaceae bacterium 
2020-11-03 | PXD021036 | Pride
Soda lakes Kulunda steppe Proteomics 1d-lc Isolate Proteome Wenzhouxiangella 
ProteomicsChaperonin CCT Checkpoint Function in Basal Transcription Factor TFIID Assembly
TFIID is a cornerstone of eukaryotic gene regulation. Distinct TFIID complexes with unique subunit composition exist and several TFIID subunits are shared with other complexes, conveying intricate cellular decision making to control subunit allocation and functional assembly of this essential transc...
ORGANISM(S): Homo sapiens (Human) 
2022-03-02 | PXD011211 | Pride
Proteomics Crystal structure Tfiid Chaperonin cct 
TranscriptomicsMotor cortex after C3 lesion
Gene expression analysis of motor cortex after spinal C3 lesion Dorsal column wire knife lesions: Adult female Fischer 344 rats weighing 150-200 gm were used. Animals underwent a laminectomy at spinal level C3. Dorsal funiculus lesions were made in the middle of C3 using a Kopf microwire device (Kop...
ORGANISM(S): Rattus norvegicus 
2016-07-01 | E-GEOD-76679 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of ID8 ovarian cancer cells after harvest from malignant ascites
Sequencing of mRNA from ID8 tumor cells and ID8 tumor cells harvested from ascites of mice 11 weeks after intra peritoneal inoculation show acquisition of cancer stem cell-like features in ascitic tumor cells.
ORGANISM(S): Mus musculus 
2020-01-06 | E-MTAB-8140 | biostudies-arrayexpress
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