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ProteomicsMolecular insights into an ancient form of Paget disease of bone
Paget disease of bone (PDB) is a chronic skeletal disorder with contemporary cases characterised by one or a few affected bones in individuals over 55 years of age. PDB-like changes have been noted in archaeological remains as old as Roman although accurate diagnoses and knowledge of the natural his...
ORGANISM(S): Homo sapiens (Human) 
2019-04-09 | PXD011743 | Pride
Paget disease Paleoproteomics Sqstm1 P62 Osteosarcoma 
ProteomicsMetalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Removal
Cytotoxicity of DNA-protein crosslinks (DPCs) is ascribed largely to their ability to block the progression of DNA replication fork. DPCs are frequently occurring in cells, either as a consequence of metabolism or exogenous agents. The mechanism of DPCs removal is not completely understood. Here, we...
ORGANISM(S): Homo sapiens (Human) 
2016-10-06 | PXD004154 | Pride
Dna-protein crosslink 
ProteomicsFBXL13 regulates centrosome homeostasis and migration through ubiquitin- mediated proteolysis
Aberrant centrosome organization with ensuing alterations of microtubule nucleation enables tumor cells to proliferate and invade despite increased genomic instability. CEP192 is a key factors in the initiation process of centrosome duplication and in the control of centrosome microtubule nucleation...
ORGANISM(S): Homo sapiens (Human) 
2018-01-16 | PXD008310 | Pride
Ubiquitin fbxl13 
ProteomicsMDC1 interacts with TOPBP1 to maintain chromosomal stability during mitosis
MDC1 is a large, modular phospho-protein scaffold that mediates recruitment of signaling and repair complexes to sites of DNA double-strand breaks (DSBs). MDC1 is anchored to damaged chromatin through interaction of its C-terminal BRCT-repeat domain with phosphorylated H2AX (γH2AX), where it recruit...
ORGANISM(S): Homo sapiens (Human) 
2019-03-25 | PXD011850 | Pride
Mdc1 topbp1 mitosis 
ProteomicsDiabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells
Diabetes is a global health problem caused primarily by the inability of pancreatic β-cells to secrete adequate levels of insulin. The molecular mechanisms underlying the progressive failure of β-cells to respond to glucose in type-2 diabetes remain unresolved. Using a combination of transcriptomics...
ORGANISM(S): Mus musculus (Mouse) 
2019-04-10 | PXD012979 | Pride
Pancreas Islets Diabetes Β-cells 
ProteomicsDetection and Quantification of Novel C-terminal TDP-43 Fragments in ALS-TDP
The pathological hallmark of amyotrophic lateral sclerosis (ALS) is the presence of cytoplasmic inclusions, containing C-terminal fragments of the protein TDP-43. Here, we tested the hypothesis that highly sensitive mass spectrometry with parallel reaction monitoring (MS-PRM) can generate a high-res...
ORGANISM(S): Homo sapiens (Human) 
2020-12-17 | PXD022186 | Pride
Prm Tdp-43 Als 
ProteomicsChronic inflammatory arthritis drives systemic changes in circadian energy metabolism
Chronic inflammation underpins many human diseases. The morbidity and mortality of chronic inflammation is often mediated through metabolic dysfunction. Inflammatory and metabolic processes vary through circadian time, suggesting an important temporal crosstalk between these systems. Using an establ...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-08 | PXD032723 | Pride
Inflammation Ceramide Rheumatoid arthritis Circadian clock Mitochondria 
ProteomicsCSF extracellular vesicle proteomics demonstrates altered protein homeostasis in amyotrophic lateral sclerosis
Extracellular vesicles (EVs) are released by neurons and glia reach the cerebrospinal fluid (CSF). Studying the proteome of CSF-derived EVs offers a novel perspective on the key intracellular processes associated with the pathogenesis of the neurodegenerative disease amyotrophic lateral sclerosis (A...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020499 | Pride
Csf Als 
ProteomicsABPP-HT - high-throughput activity-based profiling of deubiquitylating enzyme inhibitors in a cellular context
The potency and selectivity of a small molecule inhibitor are key parameters to assess during the early stages of drug discovery. In particular, it is very informative for characterizing compounds in a relevant cellular context in order to reveal potential off-target effects and drug efficacy. Activ...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2021-02-24 | PXD023036 | Pride
Drug discovery Pharmacology Activitomics Deubiquitylating enzymes Ubiquitin Automation Activity-based probes 
ProteomicsComplementary Phosphoproteomic Approaches Link IL-23R Downstream Signaling with Metabolic Adaptation in Lymphocytes
Interleukin (IL)-23 mediated signal transduction represents a major molecular mechanism underlying the pathology of inflammatory bowel disease (IBD), Crohn's disease (CD) and ulcerative colitis (UC). In addition, emerging evidence supports the role of IL-23-driven Th17 cells in inflammation. Compone...
ORGANISM(S): Homo sapiens (Human) 
2016-04-21 | PXD002990 | Pride
Phosphoproteomics il-23 
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