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Specific Aims ; To identify novel transcriptional events associated with angiogenesis in VEGF and Ang-1 stimulated rat aortic rings. Our studies take advantage of the capacity of rat aortic rings to generate new vessels in collagen gels. Rat aortic rings embedded in collagen gel immediately after e...
ORGANISM(S): Rattus norvegicus 
The promoter structure influences binding and clearance of RNA polymerase and therefore substantially influences expression of a gene. A promoter usually consists of a -10 and a -35-region, an extended -10-motif and A+T-rich upstream promoter elements. Most of these elements are optional, whereas th...
ORGANISM(S): Actinoplanes sp. SE50/110 
This experiment investigated the transcriptional response of the magnetotactic bacterium Magnetospirillum gryphiswaldense MSR1 to acute copper stress. Mid-exponential-phase cultures were exposed to five milligrams per litre copper for three hours, with untreated cultures sampled at the start and end...
ORGANISM(S): Magnetospirillum gryphiswaldense 
The experiment aimed to investigate seasonal and regional differences in gene expression in Antarctic krill in three different latitudinal regions of the Southern Ocean with variable photoperiodic conditions: South Georgia (54°S), South Orkneys/Bransfield Strait (60°S-63°S) and Lazarev Sea (62°S -66...
ORGANISM(S): Euphausia superba 
Active-site probes based on the ubiquitin scaffold have been successfully applied as tools to determine the levels of active deubiquitinating enzymes (DUBs). Here, we show the development of a Ub-based reagent selective for the DUB USP7. This concept can be applied for the generation of other new se...
ORGANISM(S): Homo sapiens (Human) 
2019-03-13 | PXD012535 | Pride
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