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ProteomicsThe histone chaperone NASP maintains H3-H4 reservoirs in the early Drosophila embryo
Histones are essential for chromatin packaging and histone supply must be tightly regulated as excess histones are toxic. To drive the rapid cell cycles of the early embryo, however, excess histones are maternally deposited. Therefore, soluble histones must be buffered by histone chaperones but the ...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2023-02-23 | PXD036809 | Pride
Histone Nasp H3-h4 Histone chaperone Ip-ms 
ProteomicsdBRWD3 manipulates chromatin signature by ubiquitination to regulate ORC
Ubiquitination and epigenetic modification both play essential roles in regulating cell fates and development, but little is known how two pathways crosstalk. A known chromatin-binding protein BRWD3, Bromodomain repeats and WD40 repeats domain contain protein 3, has been shown involved both in ubiqu...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2023-10-24 | PXD039708 | Pride
Histone Wd40 Degradation E3 ubiquitin ligase Dbrwd3 Orc 
ProteomicsBRWD3 targets KDM5/Lid for degradation to maintain H3K4 methylation levels
Histone modifications are critical for regulating chromatin structure and gene expression. Dysregulation of histone modification levels may contribute to disease development and cancer. Therefore, understanding histone modifications is essential for development and disease. The chromatin-binding pro...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2023-09-19 | PXD039706 | Pride
H3k4 Histone Degradation E3 ubiquitin ligase Brwd3 
ProteomicsComparative multiplexed interactomics of SARS-CoV-2 and homologous coronavirus non-structural proteins identifies unique and shared host-cell dependencies
Human coronaviruses (hCoV) have become a threat to global health and society, as evident from the SARS outbreak in 2002 caused by SARS-CoV-1 and the most recent COVID-19 pandemic caused by SARS-CoV-2. Despite high sequence similarity between SARS-CoV-1 and -2, each strain has distinctive virulence. ...
ORGANISM(S): Severe acute respiratory syndrome-related coronavirus Homo sapiens (Human) Betacoronavirus 
2020-12-03 | PXD022017 | Pride
Nsp2 Mitochondria-associated endoplasmic reticulum membrane Affinity purification-mass spectrometry Non-structural proteins Covid-19 Tandem mass tags Nsp4 
ProteomicsProteomic analysis of Rhizoctonia solani
Rhizoctonia solani is an important root infecting pathogen of a range of food staples worldwide including wheat, rice, maize, soybean, potato and others. Conventional resistance breeding strategies are hindered by the absence of tractable genetic resistance in any crop host. Understanding the biolog...
ORGANISM(S): Rhizoctonia solani AG-8 WAC10335 
2016-01-28 | PXD002806 | Pride
Proteomics Rhizoctonia solani Pathogen Wheat 
UnknownRetrospective evaluation of whole exome and genome mutation calls in 746 cancer samples.
Not available
S-EPMC7505971 | biostudies-literature
UnknownEffect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study.
Not available
S-EPMC8492020 | biostudies-literature
UnknownA prognostic model for use before elective surgery to estimate the risk of postoperative pulmonary complications (GSU-Pulmonary Score): a development and validation study in three international cohorts.
Not available
S-EPMC12056793 | biostudies-literature
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