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MetabolomicsDeep longitudinal multi-omics analysis of Bordetella pertussis cultivated in bioreactors highlights medium starvations and transitory metabolisms, associated to vaccine antigen biosynthesis variations and global virulence regulation

Bordetella pertussis is the bacterial causative agent of whooping cough, a serious respiratory illness. An extensive knowledge on its virulence regulation and metabolism is a key factor to ensure pertussis vaccine manufacturing process robustness. The aim of this study was to refine our ...

2023-02-21 | MTBLS5762 | MetaboLights
ProteomicsPAD2-mediated citrullination of Fibulin-5 promotes elastogenesis
The formation of elastic fibers is active only in the perinatal period. How elastogenesis is developmentally regulated is not fully understood. Citrullination is a unique form of post-translational modification catalyzed by peptidylarginine deiminases (PADIPADs), including PADIPAD1-4. Its physiologi...
ORGANISM(S): Mus musculus (Mouse) 
2021-07-22 | PXD026238 | Pride
Deiminase Elastic fiber Citrullination Deimination Lung compliance Fibulin-5 
UnknownVertical canopy gradients of respiration drive plant carbon budgets and leaf area index.
Not available
S-EPMC11883058 | biostudies-literature
ProteomicsPeptidylarginine deiminase 2 citrullinates MZB1 and promotes the secretion of IgM and IgA
MZB1 is an endoplasmic reticulum residential protein preferentially expressed in plasma cells, marginal zone and B1 B cells. Recent studies on murine B cells shows that it interacts with the tail piece of IgM and IgA heavy chain and promotes the secretion of these two classes of immunoglobulin. Howe...
ORGANISM(S): Homo sapiens (Human) 
2023-11-23 | PXD047044 | Pride
Post-translational modification Citrullination Mzb1 Rheumatoid arthritis 
MetabolomicsAntiviral metabolite 3'-Deoxy-3',4'-didehydro-cytidine is detectable in serum and identifies acute viral infections including COVID-19

BACKGROUND: There is a critical need for rapid viral infection diagnostics to enable prompt case identification in pandemic settings and support targeted antimicrobial prescribing.

METHODS: Using untargeted high-resolution liquid chromatography coupled with...

2022-02-10 | MTBLS718 | MetaboLights
ProteomicsTargeting peptidyl-arginine deiminase 4 suppresses SARS-CoV-2 replication and modulates the inflammatory response
This project presents a comprehensive, quantitative proteomics and citrullinome profiling study designed to define how viral infection remodels host protein citrullination and related cellular pathways. The experimental design integrates in vitro and in vivo models of infection, including cultured h...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-01-30 | PXD072601 | Pride
Protein arginine deiminase Inflammation Covid Lung Padi4 
MetabolomicsAn Unbiased Lipid Phenotyping Approach To Study the Genetic Determinants of Lipids and Their Association with Coronary Heart Disease Risk Factors
Direct infusion high-resolution mass spectrometry (DIHRMS) is a novel, high-throughput approach to rapidly and accurately profile hundreds of lipids in human serum without prior chromatography, facilitating in-depth lipid phenotyping for large epidemiological studies to reveal the detailed associati...
2024-02-02 | MTBLS4461 | MetaboLights
MetabolomicsMetabolic phenotyping of urine from a dementia research cohort
To better understand the molecular mechanisms underpinning physiological variation in human populations, metabolic phenotyping approaches are increasingly being applied to studies involving hundreds and thousands of biofluid samples. Hyphenated ultra-performance liquid chromatography-mass spectromet...
2022-03-01 | MTBLS719 | MetaboLights
ProteomicsFeasibility of protein turnover studies in prototroph yeast
Quantitative proteomics studies of yeast that use metabolic labeling with amino acids rely on auxotrophic mutations of one or more genes on the amino acid biosynthesis pathways. These mutations affect yeast metabolism, and preclude the study of some biological processes. Overcoming this limitation, ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2015-03-27 | PXD001823 | Pride
Yeast Protein half life Native silac Saccharomyces cerevisiae Qexactive Pulsed silac Lc-ms/ms 
ProteomicsFeasibility of protein turnover studies in prototroph yeast (auxotroph data)
uantitative proteomics studies of yeast that use metabolic labeling with amino acids rely on auxotrophic mutations of one or more genes on the amino acid biosynthesis pathways. These mutations affect yeast metabolism, and preclude the study of some biological processes. Overcoming this limitation, i...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2017-02-02 | PXD005795 | Pride
Yeast Prototroph Turnover Protein stability Auxotroph Pulsed silac 
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