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TranscriptomicsExpression data from DC-induced Hopx-deficient and sufficient regulatory T cells after immunization
We found that Hopx is required for the function of DC-induced regulatory T cells in vivo. We used microarrays to identify relevant Hopx-targets in such cells after antigenic re-challenge in vivo. CD25/Foxp3 double positive DC-induced Hopx-deficient and sufficient regulatory T cells were FACS sorted ...
ORGANISM(S): Mus musculus 
2010-08-29 | E-GEOD-23167 | biostudies-arrayexpress
TranscriptomicsCoexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells
CD4(+) type 1 T regulatory (Tr1) cells are induced in the periphery and have a pivotal role in promoting and maintaining tolerance. The absence of surface markers that uniquely identify Tr1 cells has limited their study and clinical applications. By gene expression profiling of human Tr1 cell clones...
ORGANISM(S): Homo sapiens 
2013-12-20 | E-GEOD-53514 | biostudies-arrayexpress
TranscriptomicsGenome wide transcriptional profiling of c-Cbl deficient hematopoietic stem and progenitor cells
Expression of genes that are differentially expressed between c-Cbl control and c-Cbl mutant hematopoietic stem and progenitor cells were identified through this approach. Interestingly, several leukemia associated genes, particularly transcription factors, were differentially expressed between c-Cb...
ORGANISM(S): Mus musculus 
2010-08-12 | E-GEOD-23564 | biostudies-arrayexpress
UnknownIRF8-dependent molecular complexes control the Th9 transcriptional program.
Not available
S-EPMC5727025 | biostudies-literature
OtherExecutioner Caspase-3 and 7 Deficiency Reduces Myocyte Number in the Developing Mouse Heart.
Data from PeptideAtlas, [[http://www.peptideatlas.org/PASS/PASS00689 PASS00689]]. File: JAL_DanSanc_Hrt_iTRAQ_Fr6.mzml. Published as part of PLoS One. 2015 Jun 29;10(6):e0131411 . From the Abstract: {{i}} Executioner caspase-3 and -7 are proteases promoting cell death but non-apoptotic roles are be...
ORGANISM(S): Mus_musculus_viruses, Mouse 
GPM32320017677 | GPMDB
MetabolomicsA metabolic switch orchestrated by IL-18 and the cyclic dinucleotide cGAMP programs intestinal tolerance
Tissues are exposed to diverse inflammatory challenges that shape future inflammatory responses. While cellular metabolism regulates immune function, how metabolism programs and stabilizes immune states within tissues and tunes susceptibility to inflammation is poorly understood. Here, we describe a...
2024-10-25 | MTBLS10416 | MetaboLights
UnknownCD4 T cell-intrinsic STING signaling controls the differentiation and effector functions of T<sub>H</sub>1 and T<sub>H</sub>9 cells.
Not available
S-EPMC8804688 | biostudies-literature
TranscriptomicsTracking the fate of pathogenic CD4 T helper cells in vivo.
Inflammation is a beneficial host response to infection, but it also contributes to inflammatory disease if unregulated. The Th17 lineage of T helper (Th) cells can cause severe human inflammatory diseases. These cells exhibit both instability (i.e., they can cease to express their signature cytoki...
ORGANISM(S): Mus musculus 
2015-04-25 | E-GEOD-68242 | biostudies-arrayexpress
UnknownVasopressor use after noncardiac surgery: an international observational study.
Not available
S-EPMC12799376 | biostudies-literature
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