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ProteomicsMass spectrometry of excretory/secretory products (ectosomes, exosomes, and soluble proteins) secreted by Toxoplasma gondii tachyzoites isolated from an infected murine model.
Toxoplasma gondii is an intracellular parasite that infects all nucleated cells; to date, this organism is considered as one of the most successful parasites in the world. During infection, internalization, and proliferation the parasite excretes/secretes a high number of proteins, several of them w...
ORGANISM(S): Toxoplasma gondii GT1 
2019-08-29 | PXD013767 | Pride
Toxoplasma gondii. Quantification Excretory/secretory products Mass spectrometry Ectosomes Exosomes 
ProteomicsProteomic characterization of the pellicle of Toxoplasma gondii
Toxoplasma gondii is an obligate intracellular parasite. The ability to invade cells and proliferate successfully is given by the machinery found in the pellicle of the parasite, the pellicle is a complex of three membranes. Despite the importance of the pellicle in the biology of Toxoplasma, its pr...
ORGANISM(S): Toxoplasma gondii 
2021-02-16 | PXD022398 | Pride
Toxoplasma Mass spectrometry Protein quantification Adhesion Srs Pellicle 
ProteomicsQuantitative proteomic analysis of the Toxoplasma gondii cytoskeleton and bioinformatic identification of highly antigenic proteins
The Toxoplasma gondii cytoskeleton is a highly organized structure essential for parasite motility, replication, and host cell invasion. To identify its components, a highly enriched fraction of tachyzoite cytoskeletons was obtained and quantitatively analyzed by mass spectrometry (LC/ESI/HDMSE). We...
ORGANISM(S): Eukaryota Toxoplasma gondii RH 
2025-08-04 | PXD063409 | Pride
Toxoplasma gondii Quantitative mass spectrometry Immunogenic peptides Cytoskeleton 
UnknownDesign, Synthesis, and Characterization of Stapled Oligosaccharides.
Not available
S-EPMC9562281 | biostudies-literature
TranscriptomicsCopy number abnormality, MYC activity and the genetic fingerprint of normal B-cells and the microRNA profile of DLBCL-77
A better understanding of the pathogenesis of diffuse large B-cell lymphoma (DLBCL) has clarified its relationship to normal B-cells, pointed to distinct mechanisms of cell transformation, and facilitated the design of novel treatments. However, these data derive from mRNA genes studies, whereas ge...
ORGANISM(S): Homo sapiens 
2010-06-22 | E-GEOD-15177 | biostudies-arrayexpress
UnknownUnderutilized Mexican Plants: Screening of Antioxidant and Antiproliferative Properties of Mexican Cactus Fruit Juices.
Not available
S-EPMC7918198 | biostudies-literature
TranscriptomicsEffects of depleting the Pkh activity in yeast.
The yeast proteins Pkh1 and Pkh2 are functional counterparts of the mammalian 3-phosphoinositide-dependent protein kinase 1 (PDK1). Cells carrying simultaneous deletion in both genes, PKH1 and PKH2 are not viable, at least in some genetic backgrounds (Casamayor et al., 1999; Inagaki et al., 1999). C...
ORGANISM(S): Saccharomyces cerevisiae 
2015-04-30 | E-GEOD-32623 | biostudies-arrayexpress
TranscriptomicsTranscriptional response to heat shock in Pkh-depleted yeast cells.
The yeast proteins Pkh1 and Pkh2 are functional counterparts of the mammalian 3-phosphoinositide-dependent protein kinase 1 (PDK1). Cells carrying simultaneous deletion in both genes, PKH1 and PKH2 are not viable, at least in some genetic backgrounds (Casamayor et al., 1999; Inagaki et al., 1999). C...
ORGANISM(S): Saccharomyces cerevisiae 
2015-04-30 | E-GEOD-33904 | biostudies-arrayexpress
TranscriptomicsStaphVar-DNA microarray analysis of accessory genome of community-acquired methicillin resistant Staphylococcus aureus
Approximatively 75% of the genome of S. aureus (“core” genome) are highly conserved between strains, whereas the remaining 25% (“accessory” genome) are composed of variable regions that are mostly composed of mobile genetic elements (MGE), containing virulence and resistance genes. We have developed...
ORGANISM(S): Staphylococcus aureus 
2009-02-14 | E-GEOD-13702 | biostudies-arrayexpress
TranscriptomicsA Systems Biology Approach Reveals Common Metastatic Pathways in Osteosarcoma
Background Osteosarcoma (OS) is the most common malignant bone tumor in children and adolescents. The survival rate of patients with metastatic disease remains very dismal. Nevertheless, metastasis is a complex process and a single-level analysis is not likely to identify its key biological determi...
ORGANISM(S): Homo sapiens 
2012-04-24 | E-GEOD-37552 | biostudies-arrayexpress
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