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ProteomicsHuh-7 Over-expression FNDC4 LC-MS
To clarify the molecular mechanism by which FNDC4 promotes HCC invasion, mass spectrometry (MS) analysis was performed on the lysates of Huh-7-overexpressing FNDC4 and normal Huh-7 cells.
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD025623 | Pride
Liver cancer Fndc4 Lc-ms 
TranscriptomicsTreatment of bone marrow-derived macrophages with hFc-FNDC4 recombinant protein
FNDC4 is a novel secreted factor sharing high homology with the exercise-associated myokine irisin (FNDC5). Here we report that Fndc4 is robustly upregulated in various mouse models of inflammation as well as in human inflammatory conditions. Specifically, subjects with inflammatory bowel disease sh...
ORGANISM(S): Mus musculus 
2016-04-12 | GSE76172 | GEO
UnknownFNDC4 Drives Metastasis and Immune Evasion in Pancreatic Cancer.
Not available
S-EPMC12809120 | biostudies-literature
GenomicsFNDC4 alleviates cardiac ischemia/reperfusion injury through facilitating HIF1α-dependent cardiomyocyte survival and angiogenesis in male mice
FNDC4 alleviates cardiac ischemia/reperfusion injury through facilitating HIF1α-dependent cardiomyocyte survival and angiogenesis in male mice
PRJNA1163681 | ENA
GenomicsSingle-nuclei RNA-seq of neural organoids generated from wildtype and FNDC4 KO iPSCs
Single-nuclei RNA-seq of neural organoids generated from wildtype and FNDC4 KO iPSCs
PRJNA1201214 | ENA
TranscriptomicsFNDC4 alleviates cardiac ischemia/reperfusion injury through facilitating HIF1α-dependent cardiomyocyte survival and angiogenesis in male mice
Fibronectin type III domain-containing (FNDC) proteins play critical roles in cellular homeostasis and cardiac injury, and our recent findings define FNDC5 as a promising cardioprotectant against doxorubicin- and aging-related cardiac injury. FNDC4 displays a high homology with FNDC5; however, its r...
ORGANISM(S): Mus musculus 
2024-10-08 | GSE277729 | GEO
UnknownCorrelation of the prognostic value of FNDC4 in glioblastoma with macrophage polarization.
Not available
S-EPMC9440505 | biostudies-literature
TranscriptomicsSingle-nuclei RNA-seq of neural organoids generated from wildtype and FNDC4 KO iPSCs
Large-cohort genome-wide association studies (GWAS) for alcohol use disorder (AUD) risk and drug treatment outcomes have identified significant genetic loci that are splicing quantitative trait loci (sQTLs) for the FNDC4 gene in multiple human brain regions. However, in spite of the fact that FNDC4 ...
ORGANISM(S): Homo sapiens 
2025-06-16 | GSE285126 | GEO
UnknownFNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice.
Not available
S-EPMC4832079 | biostudies-literature
UnknownAlcohol use disorder-associated gene FNDC4 alters glutamatergic and GABAergic neurogenesis in neural organoids.
Not available
S-EPMC12948423 | biostudies-literature
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