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ProteomicsATM promotes reversed fork processing during DNA interstrand cross-link repair
During replication-coupled DNA interstrand cross-link (ICL) repair, fork reversal is thought to enable the Fanconi anemia (FA) pathway to resolve the ICL through nucleolytic incisions. Subsequent fork restoration then allows nascent DNA strand extension past the lesion. Although these fork remodelin...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2026-08-25 | PXD071242 | Pride
Fork reversal Interstrand cross-link Exo1 Icl repair Pp2a Fanconi anemia pathway Dna2 Atm Fork restoration Orbitrap astral mass spectrometer Wrn 
ProteomicsProteomic profiling reveals distinct phases to the restoration of chromatin following DNA replication
Chromatin organization must be maintained during cell proliferation to preserve cellular identity and genome integrity. However, DNA replication results in transient displacement of DNA bound proteins, and it is unclear how they regain access to newly replicated DNA. Using quantitative MS-based prot...
ORGANISM(S): Homo sapiens (Human) 
2023-02-02 | PXD038376 | Pride
Tmt Proteomics 
UnknownRestoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers.
Not available
S-EPMC5720682 | biostudies-literature
UnknownCooperation of RAD51 and RAD54 in regression of a model replication fork.
Not available
S-EPMC3064783 | biostudies-literature
UnknownMUS81-EME2 promotes replication fork restart.
Not available
S-EPMC5092538 | biostudies-literature
UnknownCleavage of a model DNA replication fork by a Type I restriction endonuclease.
Not available
S-EPMC2699502 | biostudies-literature
UnknownThe Fml1-MHF complex suppresses inter-fork strand annealing in fission yeast.
Not available
S-EPMC6952179 | biostudies-literature
UnknownDisparate requirements for RAD54L in replication fork reversal.
Not available
S-EPMC11551752 | biostudies-literature
UnknownATM promotes reversed fork processing during DNA interstrand cross-link repair.
Not available
S-EPMC12632361 | biostudies-literature
ProteomicsProteomic profiling reveals distinct phases to the restoration of chromatin following DNA replication
Chromatin organization must be maintained during cell proliferation to preserve cellular identity and genome integrity. However, DNA replication results in transient displacement of DNA bound proteins, and it is unclear how they regain access to newly replicated DNA. Using quantitative MS-based prot...
ORGANISM(S): Homo sapiens (Human) 
2023-02-02 | PXD038113 | Pride
Proteomics Lc-ms Tmt 
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