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ProteomicsTitle Page Cardiac Gene Therapy Rescues Diabetic Cardiomyopathy and Lowers Blood Glucose
Diabetic cardiomyopathy, an increasingly global epidemic and a major cause of heart failure with preserved ejection fraction (HFpEF), is associated with hyperglycemia, insulin resistance, and intra-cardiomyocyte calcium mishandling. Here we identify that, in db/db mice with type 2 diabetes induced H...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD044236 | Pride
Calcium handling Transverse-tubule microdomain Gene therapy Glucose uptake Diabetic cardiomyopathy 
ProteomicsParacrine Signaling in Visceral Fat
Accumulation of visceral (VIS) as opposed to subcutaneous (SUB) fat is a predictor of metabolic disorders, insulin resistance, and cardiovascular disease. This is due in part to the limited capacity of VIS fat to buffer lipids allowing them to deposit in insulin-sensitive tissues, thus impairing ins...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-21 | PXD014672 | Pride
Paracrine signaling Mouse Visceral fat 
ProteomicsProteomic Characterization of Cardioprotective Human Acellular Amniotic Fluid
Amniotic fluid-derived products are a promising resource for cell therapy and tissue engineering due to their anti-inflammatory, angiogenic, and antifibrotic properties. Human amniotic fluid (hAF) has been used in medical applications such as wound healing, skin disorders, and ophthalmic conditions....
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD053775 | Pride
Human Amniotic fluid Proteomics Lc-ms/ms 
ProteomicsHistone H4K20 Trimethylation is Decreased in Murine Models of Heart Disease
Heart disease is the leading cause of death in the developed world, and its comorbidities such as hypertension, diabetes, and heart failure are accompanied by major transcriptomic changes in the heart. During cardiac dysfunction, which leads to heart failure, there are global epigenetic alterations ...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-14 | PXD031617 | Pride
Mouse Sham Lysate Lvad Wt Po 
ProteomicsDistinct transcriptomic and proteomic profile specifies heart failure patients with potential of myocardial recovery upon circulatory support and mechanical unloading
Phosphoproteomic Analysis of LVAD assisted human heart samples.
ORGANISM(S): Homo sapiens (Human) 
2023-02-27 | PXD016761 | Pride
Heart Phosphoproteomics Human 
ProteomicsMCU activity compensates for Complex I dysfunction
Co-immunoprecipitation experiments were performed in HEK293T cells in the absence and presence of Flag-tagged MCU and binding proteins were identified by tandem mass spectrometry.
ORGANISM(S): Homo sapiens (Human) 
2022-03-10 | PXD018742 | Pride
Mitochondria Label-free Heart Co-ip Lc-ms/ms 
TranscriptomicsPramipexole induced place preference promoted after L-dopa therapy and nigral dopaminergic loss: linking behavior to transcriptional modifications
Symptoms of the dopamine dysregulation syndrome in patients with Parkinson’s disease (PD) are close to those observed in psychostimulant addiction. This suggests that dopamine replacement therapy shares some properties with potentially addictive drugs. A remaining challenge is to understand the ne...
ORGANISM(S): Rattus norvegicus 
2015-10-28 | E-GEOD-74382 | biostudies-arrayexpress
TranscriptomicsFunctional characterization of DNA methylation in the oligodendrocyte lineage [RNASeq_development]
Myelination in the CNS is modulated by interplay between transcription factors and recruitment of chromatin modifying enzymes. Using a network built from genome-wide DNA methylation and transcriptomic profiling of sorted oligodendrocyte lineage cells that integrates oligodendrocyte-specific ChIP-Seq...
ORGANISM(S): Mus musculus 
2016-04-14 | E-GEOD-66029 | biostudies-arrayexpress
GenomicsFunctional characterization of DNA methylation in the oligodendrocyte lineage [ERRBS]
Myelination in the CNS is modulated by interplay between transcription factors and recruitment of chromatin modifying enzymes. Using a network built from genome-wide DNA methylation and transcriptomic profiling of sorted oligodendrocyte lineage cells that integrates oligodendrocyte-specific ChIP-Seq...
ORGANISM(S): Mus musculus 
2016-04-14 | E-GEOD-66028 | biostudies-arrayexpress
TranscriptomicsAfter demyelination in the adult CNS, oligodendrocyte precursor cells revert to an immature mRNA profile and express immune cues favoring their migration
In multiple sclerosis (MS) and experimental models of demyelination, myelin repair is mostly achieved by oligodendrocyte precursor cells (OPCs). To gain insight into the biological specificity of these adult precursors, in the perspective to better understand why remyelination often fails in MS, we ...
ORGANISM(S): Mus musculus 
2014-11-06 | E-GEOD-48872 | biostudies-arrayexpress
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