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TranscriptomicsGlucocorticoid Resistance Gene Profiling in T-ALL Cell Lines
Baseline glucocorticoid resistance profiles were measured in a panel of 15 paediatric T-Cell acute lymphoblastic leukaemia cell lines and correlated with Affymetrix Gene expression to identify genes and pathways associated with drug resistance in T-ALL. The cell lines' resistance to Methylprednisolo...
ORGANISM(S): Homo sapiens 
2012-07-09 | E-MTAB-1208 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of bone marrow from children with T-cell acute lymphoblastic leukamia comparing those who remained in continuous complete remission with those that relapsed
We compared the gene expression profile from a group of children with T-cell acute lymphoblastic leukamia who remained in continuous complete remission (CCR) (n = 7) with that from a group who relapsed (n = 5), using Affymetrix HG-U133A arrays. Using the decision-tree based supervised learning algor...
ORGANISM(S): Homo sapiens 
2008-04-04 | E-TABM-255 | biostudies-arrayexpress
TranscriptomicsMolecular diagnosis of T cell and/or antibody-mediated rejection in human kidney transplant biopsies
Histologic diagnosis of T cell-mediated rejection in kidney transplant biopsies has limited reproducibility because it is based on non-specific lesions using arbitrary rules that are subject to differing interpretations. We used microarray results from 403 indication biopsies previously given histol...
ORGANISM(S): Homo sapiens 
2013-02-13 | E-GEOD-36059 | biostudies-arrayexpress
TranscriptomicsHnRNPLL is a global regulator of alternative splicing in activated T cells
HnRNPLL was identified as a critical regulator of CD45 alternative splicing in a lentiviral shRNA screen. RNAi-mediated depletion of hnRNPLL eliminated the activation-induced induced transition from the CD45RA to the CD45RO isoform. HnRNPLL is induced during the process of T cell activation, raising...
ORGANISM(S): Homo sapiens 
2010-09-15 | E-GEOD-11834 | biostudies-arrayexpress
TranscriptomicsRelation between T CD4+: Regulatory cells and IL-2 producing cells
We previously proposed that lymphocyte homeostasis is achieved by a quorum-sensing like mechanism, based on the paracrine sensing of IL-2 by Foxp3(+) regulatory T CD4(+) cells. In turn, these cells will suppress IL-2 producing cells, thereby controlling the total number of T CD4(+) cells. As CD4(+) ...
ORGANISM(S): Mus musculus 
2015-02-01 | E-GEOD-54686 | biostudies-arrayexpress
TranscriptomicsCD2 distinguishes two subsets of human plasmacytoid dendritic cells with distinct phenotype and functions
Plasmacytoid dendritic cells (pDCs) are key regulators of anti-viral immunity. They rapidly secrete IFN-alpha and cross-present viral antigens thereby launching adaptive immunity. Here we show that activated human pDCs inhibit replication of cancer cells, and kill them in a contact dependent fashion...
ORGANISM(S): Homo sapiens 
2009-05-21 | E-GEOD-15215 | biostudies-arrayexpress
TranscriptomicsQuorum sensing in CD4+ T cells homeostasis : IL-2 coordinates the interplay between IL-2p and regulatory T cells.
Many species of bacteria use quorum sensing to sense the amounts of secreted metabolites and adapt their growth according to their population density. We asked whether similar mechanisms would operate in lymphocyte homeostasis. We investigated the regulation of the size of Interleukin-2-producing CD...
ORGANISM(S): Mus musculus 
2013-11-01 | E-GEOD-50149 | biostudies-arrayexpress
ProteomicsPhosphoproteomic analysis of CAR T cells
Quantitative phosphoproteomics of CAR T constructs with different transmembrane areas
ORGANISM(S): Homo sapiens (Human) 
2025-08-21 | PXD053205 | Pride
Proteomics Lc-ms Tmtpro 
UnknownProgrammed Cell Death Ligand (PD-L)-1 Contributes to the Regulation of CD4+ T Effector and Regulatory T Cells in Cutaneous Leishmaniasis.
Not available
S-EPMC7642203 | biostudies-literature
UnknownExtramedullary T-lymphoblastic Crisis in a Myelodysplastic/Myeloproliferative Neoplasm with a t(12;22)/MN1::ETV6 Translocation.
Not available
S-EPMC10048276 | biostudies-literature
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