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ProteomicsThe Amino-Terminal Part of Human Filaggrin-2 is a Component of Cornified Envelopes
Filaggrin-2 (FLG2), a member of the S100-fused type protein family, is a 250 kDa protein mainly expressed in differentiated keratinocytes of the epidermis (Wu et al., 2009; Hsu et al., 2011). Its expression is reduced in atopic dermatitis (Pellerin et al., 2013), and heterozygous non-sense mutations...
ORGANISM(S): Homo sapiens (Human) 
2019-02-25 | PXD011833 | Pride
Keratinocyte Proteomics Corneocyte Transglutaminase Terminal differentiation Epidermis 
ProteomicsAnalysis of 5000 year-old human teeth using optimized large-scale and targeted proteomics approaches for detection of sex-specific peptides
Tooth is a remarkable source of information for paleoanthropologists. Investigation of ancient dental proteomes is able to provide biomolecular data helping at understanding past life. In particular, the enamel protein amelogenin (AMEL) offers the possibility to determine the sex of the specimen. He...
ORGANISM(S): Homo sapiens (Human) 
2019-11-13 | PXD014442 | Pride
Sex determination Amelogenin Data dependent acquisition Tooth Paleoproteomics Parallel reaction monitoring 
ProteomicsHA-MOP knockin mice express the canonical µ-opioid receptor but lack detectable splice variants
G protein-coupled receptors (GPCRs) are notoriously difficult to detect in native tissues. In an effort to resolve this problem, we have developed a novel mouse model by fusing the hemagglutinin (HA)-epitope tag sequence to the amino-terminus of the µ-opioid receptor (MOP). Although HA-MOP knock-in ...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-07 | PXD027825 | Pride
Brain Mouse Pharmacology Mop splice variants Opioid receptor family Nanolc-ms/ms cid/etd Phosphorylation 
ProteomicsAgonist-selective NOP receptor phosphorylation correlates in vitro and in vivo and reveals differential post-activation signaling by chemically diverse agonists
Agonists for the nociceptin/orphanin FQ opioid peptide NOP receptor, a member of the opioid receptor family, are under active investigation as novel analgesics, but their modes of signaling are less well characterized than those for other members of the opioid receptor family. Therefore, we investig...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-26 | PXD012908 | Pride
Brain Opioid receptor family Mouse Biological Pharmacology Post-translational modification Nanolc-ms/ms cid/etd Phosphorylation 
ProteomicsLong non-coding RNA Neat1 is a key of translational regulator in hypoxia
Internal ribosome entry sites (IRESs) drive translation initiation during stress. In response to hypoxia, (lymph)angiogenic factors responsible for tissue revascularization in ischemic diseases are induced by the IRES-dependent mechanism. Here we searched for IRES trans-acting factors (ITAFs) active...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-03 | PXD024067 | Pride
Nanolc-ms/ms Translational control Hypoxia Cardiomyocyte Label-free quantitative proteomics 
ProteomicsTargeting Fibrillarin-mediated ribosomal RNA maturation as a novel therapeutic vulnerability in triple-negative breast cancer
Triple-negative breast cancer (TNBC) is among the most challenging breast cancer subtypes to treat due to the lack of effective therapeutic options. Ribosome biogenesis has recently emerged as a promising therapeutic target across various cancers. Current ribosome biogenesis inhibitors primarily tar...
ORGANISM(S): Homo sapiens (Human) 
2025-11-24 | PXD060027 | Pride
Label-free quantitative proteomics Targeting ribosome biogenesis Nanolc-ms/ms Triple-negative breast cancer 
ProteomicsMitochondrial ribosomal protein MRPS15 Is a component of cytosolic ribosomes and regulates translation in stressed cardiomyocytes
Regulation of mRNA translation is a crucial step in controlling gene expression in stressed cells, impacting many pathologies, including heart ischemia. In recent years, ribosome heterogeneity has emerged as a key control mechanism driving the translation of subsets of mRNAs. In this study, we inves...
ORGANISM(S): Homo sapiens (Human) 
2024-06-23 | PXD050321 | Pride
Ribosome heterogeneity  mitochondrial ribosomal protein  translational control  ires  endoplasmic reticulum stress  cardiomyocyte  proteomics 
ProteomicsAttachment of the RNA degradosome to the inner cytoplasmic membrane of Escherichia coli prevents wasteful degradation of rRNA intermediates in ribosome assembly.
RNase E, an essential endoribonuclease in Escherichia coli, is the key component of the multienzyme RNA degradosome, which is localized to the inner cytoplasmic membrane. Until now, the reason for membrane localization of RNase E was not known. We have analyzed ribosome assembly in the rneΔMTS strai...
ORGANISM(S): Escherichia coli 
2023-01-16 | PXD038317 | Pride
Ribosome assembly Rnase e Rna degradosome Label-free quantitative proteomics Nanolc-ms/ms 
ProteomicsReduced collagen degradation in pelvic urine precedes kidney fibrosis induced by unilateral ureteral obstruction
Kidney fibrosis is a major hallmark of chronic kidney disease and is defined by an excessive accumulation of extracellular matrix, primarily collagens. While collagen synthesis has been extensively investigated, the contribution of impaired collagen degradation to the development of fibrosis remains...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-12 | PXD064569 | Pride
Chronic kidney disease Kidney fibrosis Urine Unilateral ureteral obstruction Ce-ms/ms 
ProteomicsDevelopment of a capillary electrophoresis coupled to mass spectrometry pipeline for comparable assessment of the plasma peptidome
Although capillary electrophoresis coupled to mass spectrometry (CE-MS) holds promise for urinary peptide profiling, only a limited number of studies have used CE-MS to study plasma peptides. Here we describe the establishment of a workflow, including sample preparation, CE-MS and MS/MS analyses, da...
ORGANISM(S): Homo sapiens (Human) 
2025-05-16 | PXD056224 | Pride
Chronic kidney disease Plasma Cardiovascular diseases Peptidome Biomarkers Ce-ms/ms 
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