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TranscriptomicsTranscription profiling of mouse frontal cortex after treatment with zntipsychotic drugs
Antipsychotic drugs are classified as typical and atypical based on extrapyramidal effects. However, since the frontal cortex is one of the most important regions for antipsychotic actions, this study attempted to classify antipsychotic drugs based on gene expression in the frontal cortex. Chlorprom...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-1501 | biostudies-arrayexpress
ProteomicsEffect of Juvenile Environmental Tobacco Smoke Exposure on the Rat Frontal Cortex Neuroproteome
Exposure to secondhand tobacco smoke during early childhood has been linked with an increased risk for behavioral disorders, yet little is known regarding how brain development is impacted. Using an environmental tobacco smoke (ETS) passive inhalation model, this study assesses the neurodevelopmenta...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-12-17 | PXD011744 | Pride
Tobacco Juvenile Hdmse Neuroproteome Rat Brain Frontal Secondhand smoke Cortex Development 
ProteomicsEffect of Juvenile Environmental Tobacco Smoke Exposure on the Rat Frontal Cortex Neuroproteome
Exposure to secondhand tobacco smoke during early childhood has been linked with an increased risk for behavioral disorders, yet little is known regarding how brain development is impacted. Using an environmental tobacco smoke (ETS) passive inhalation model, this study assesses the neurodevelopmenta...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-05-26 | PXD007690 | Pride
Tobacco Juvenile Hdmse At Neuroproteome Brain Frontal Secondhand smoke Cortex Development 
TranscriptomicsTranscription profiling of response of Rattus norvegicus frontal cortex to chronic olanzapine treatment
Male Sprague-Dawley albino rats (Charles River) initially weighting approximately 200 grams were randomly assigned to one of the following: 1) olanzapine (2 mg/kg/day, I.P.) (N=20) or 2) Saline (N=20) and administered olanzapine or saline for 21 days. Frontal cortex (N=4/group) was dissected and ho...
ORGANISM(S): Rattus norvegicus 
2007-11-03 | E-GEOD-2547 | biostudies-arrayexpress
TranscriptomicsMicroarrays of frontal cortex (area 8) of Parkinson cases and controls
Microarrays of frontal cortex (area 8) of Parkinson cases and controls
ORGANISM(S): Homo sapiens 
2013-06-02 | E-MTAB-1194 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human prefrontal cortex during postnatal development
Fresh frozen post mortem prefrontal cortex tissue (Brodman area 46) was obtained from 44 individuals varying in age from 0 to 49 years. RNA was extracted from these samples and hybridized to HG133plus2.0 GeneChips. The data was used to examine patterns of gene expression over the course of human pos...
ORGANISM(S): Homo sapiens 
2009-12-02 | E-GEOD-13564 | biostudies-arrayexpress
TranscriptomicsmiRNA expression profiles of frontal cortex and hippocampus from adult C57BL/6J mice
We used Affymetrix miRNA arrays to analyze the expression of miRNAs in the frontal cortex and hippocampus of 8-week-old C57BL/6J wt mice. We compared these microarray-based expression profiles to ones obtained by miRNA sequencing from the same brain regions of the same mouse strain. miRNA expression...
ORGANISM(S): Mus musculus 
2011-06-22 | E-GEOD-27891 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse prefrontal cortex of C57Bl/6J mice at Zeitgeber Time (ZT) 3, 9, 15, and 21.
Background: The prefrontal cortex is important in regulating sleep and mood. Diurnally regulated genes in the prefrontal cortex may be controlled by the circadian system, by the sleep-wake states, or by cellular metabolism or environmental responses. Bioinformatics analysis of these genes will provi...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9471 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human frontal cortices from individuals with Retts syndrome
Four sets of six microarray experiments were conducted. Six individual RTT frontal cortices were co-hybridized with six individual control frontal cortices. For example, the frontal cortex of patient RTT1 was compared with the occipital cortex of RTT1. Additionally, where the frontal cortex of a RTT...
ORGANISM(S): Homo sapiens 
2010-03-07 | E-MEXP-2588 | biostudies-arrayexpress
GenomicsDevelopmental Regulation and Individual Differences of Neuronal Epigenomes in the Prefrontal Cortex
We report global distribution of trimethylated Histone H3 Lysine 4 (H3K4me3) in human prefrontal cortex neurons at different ages Neuronal nuclei from human prefrontal cortex were isolated by FACS. Regions marked by H3K4me3 were identified by chromatin immunoprecipiation followed by deep sequencing.
ORGANISM(S): Homo sapiens 
2010-04-20 | E-GEOD-21172 | biostudies-arrayexpress
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