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ProteomicsProteomics of Fuchs Endothelial Corneal Dystrophy support that the extracellular matrix of Descemet¹s membrane is Disordered
Fuchs’ endothelial corneal dystrophy is major corneal disorder in the western world affecting the innermost part of the cornea, which leads to visual impairment. The morphological changes observed in Fuchs’ endothelial corneal dystrophy is well described, however, much less in known of the pathology...
ORGANISM(S): Homo sapiens (Human) 
2014-05-27 | PXD000746 | Pride
Itraq quantification Fuchs' endothelial corneal dystrophy Xic quantification 
ProteomicsTCF4 trinucleotide repeat expansion drives distinct proteomic signatures in Fuchs endothelial corneal dystrophy
The aims of this study were to use an isogenic cell model system to investigate the proteomic consequences of TCF4 trinucleotide repeat expansion in Fuchs endothelial corneal dystrophy (FECD) and to identify potential molecular pathways contributing to disease pathogenesis. We used our previously es...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD075094 | Pride
Retina Fuchs endothelial corneal dystrophy (fecd) Ctg repeat 
ProteomicsBlockade of mitochondrial components release by exosome pathway promotes the pathogenesis of Fuchs endothelial corneal dystrophy
Fuchs endothelial corneal dystrophy (FECD) is the leading indication of corneal transplantation worldwide and the focus of pathogenesis has been on the corneal endothelium. Instead of cellular analysis, we aimed to identify the protein changes of aqueous humor (AH) in patients with FECD and investig...
ORGANISM(S): Homo sapiens (Human) 
2026-01-23 | PXD065309 | Pride
Fuchs endothelial corneal dystrophy  proteomics  aqueous humor  corneal endothelium  mitochondrial quality control 
UnknownGenetic mutations and molecular mechanisms of Fuchs endothelial corneal dystrophy.
Not available
S-EPMC8204469 | biostudies-literature
UnknownPolymorphisms of IL23R and Fuchs' syndrome in a Chinese Han population.
Not available
S-EPMC3000233 | biostudies-literature
UnknownNo evidence for interference of h&e staining in DNA testing: usefulness of DNA extraction from H&E-stained archival tissue sections.
Not available
S-EPMC3383644 | biostudies-literature
ProteomicsDual-targeting 5-nitroimidazole ethers eradicate H. pylori by induction of stress and disabling its adaptive response
Metronidazole represents a front line-drug against Helicobacter pylori. To unravel its largely unknown cellular targets, we performed activity-based protein profiling (ABPP). Surprisingly, an alkynylated ether probe (Metro-P3) exhibited a 60-fold enhanced potency. Chaperonin HpGroEL and thiol peroxi...
ORGANISM(S): Staphylococcus schleiferi Staphylococcus pseudintermedius 
2026-04-13 | PXD067473 | Pride
Abpp Lc-msms Bacteria 
UnknownSite-Selective C-H Functionalization of (Hetero)Arenes via Transient, Non-Symmetric Iodanes.
Not available
S-EPMC6481961 | biostudies-literature
UnknownRupintrivir reduces RV-induced TH-2 cytokine IL-4 in precision-cut lung slices (PCLS) of HDM-sensitized mice ex vivo.
Not available
S-EPMC6805592 | biostudies-literature
ProteomicsSmall Proteome of Haloferax volcanii - Proteogenomic database search strategy
The small proteome has already been well explored in eukaryal and bacterial species, but so far, archaeal genomes have not yet been analysed broadly with a dedicated focus on small proteins. Here, we present a combinatorial approach, integrating experimental information from small protein-optimized ...
ORGANISM(S): Haloferax volcanii (Halobacterium volcanii) 
2023-02-01 | PXD031691 | Pride
Sep Archaea Sprotein Proteogenomics Database search Sorf Small protein enrichment Top-down Ribosome profiling Haloferax volcanii Small protein Proteolytic digest 
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