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Robust colonic epithelial regeneration and amelioration of colitis via FZD-specific activation of Wnt signaling
Background and aims: Current management of inflammatory bowel disease (IBD) leaves a clear unmet need to treat the severe epithelial damage. Modulation of Wnt signaling might present an opportunity to achieve histological remission and mucosal healing when treating IBD. Exogenous R-spondin (RSPO), w...
ORGANISM(S): Mus musculus 
2022-05-19 | GSE201723 | GEO
Tiki antagonizes Wnt3a signaling by cleaving and inactivating Wnt3a in Wnt-producing cells. Tiki also functions in Wnt-receiving cells to antagonize Wnt signaling by an unknown mechanism. Here, we demonstrate that Tiki inhibition of Wnt signaling at the cell surface requires Frizzled receptors. Tiki...
ORGANISM(S): Homo sapiens (Human) 
2023-05-24 | PXD040942 | Pride
Wnt signaling is critical for the development and maintenance of many cell lineages, including hematopoietic stem cells (HSCs). Tight regulation of Wnt signals is essential, as overactivation can drive tumorigenesis. Numerous Wnt ligands and Frizzled (Fzd) receptors exist, and the negative regulatio...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) Helicobacter pylori J99 (Campylobacter pylori J99) 
2025-08-08 | PXD066969 | Pride
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