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Frizzled receptors facilitate Tiki inhibition of Wnt signaling at the cell surface

Tiki antagonizes Wnt3a signaling by cleaving and inactivating Wnt3a in Wnt-producing cells. Tiki also functions in Wnt-receiving cells to antagonize Wnt signaling by an unknown mechanism. Here, we demonstrate that Tiki inhibition of Wnt signaling at the cell surface requires Frizzled receptors. Tiki...

ORGANISM(S): Homo sapiens (Human)

2023-05-24 | PXD040942 | Pride