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Acephalic spermatozoa syndrome is severe teratozoospermia, displaying the separation of the sperm head and tail. In 2015, we first reported that genetic ablation of SPATA6 results in the separation of sperm head and tail. Here, we focus on a co-chaperone protein BAG5 that interacts with SPATA6 and e...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-14 | PXD042965 | Pride
Our work recognized heterogeneous nuclear ribonucleoprotein R (hnRNPR) is a master regulator of m6A-dependent pre-mRNA splicing. Genetic mutation in HNRNPR leads to asthenoteratozoospermia in both humans and mice, culminating in complete sterility. Mechanistically, genetic ablation of Hnrnpr manifes...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-13 | PXD067981 | Pride
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