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ProteomicsBoth wnt signaling and epidermal stem cell-derived exosomes are involved in epidermal development
Millions suffer from skin diseases. Functional epidermal stem cells are needed in skin therapy or drug screening in vitro. We obtained functional epidermal stem cells with intact stemness and cell junctions by treating them with wnt3a. Moreover, epidermal stem cell-derived exosomes were useful in ep...
ORGANISM(S): Homo Sapiens 
PXD020351 |
ProteomicsSerum proteome profiling provides a deep understanding of the “gut–liver axis” in relation to liver injury and regeneration
The gut–liver axis is one of the major contributors to the transport of products from the intestine or intestinal microbes with the progression of liver regeneration. However, the influence of proteins from the hepatic portal vein (HPV), the bridge of enterohepatic circulation, on liver regeneration...
ORGANISM(S): Mus Musculus 
2020-05-15 | PXD019212 |
ProteomicsThe Matrisome Reveals the Characterization of Skin Keloid Microenvironment
Keloids are fibroproliferative dermal tumors of unknown origin that are characterized by the overabundant accumulation of extracellular matrix (ECM) components. The mechanism of keloid formation has remained unclear because of a poor understanding of its molecular basis. In this study, the dermal EC...
ORGANISM(S): Homo Sapiens 
2020-05-08 | PXD019052 |
ProteomicsProteomic identification of new diagnostic biomarkers of early-stage cutaneous mycosis fungoides
Primary cutaneous T-cell lymphoma (CTCL) is responsible for two-thirds of cutaneous lymphoma cases. Mycosis fungoides (MF), the most common subtype of CTCL comprises approximately 60% of CTCLs. Due to the similar clinical features of MF and inflammatory diseases such as eczema and psoriasis, early-s...
ORGANISM(S): Homo Sapiens 
2020-11-28 | PXD022798 |
ProteomicsSpatially region resolved proteomic map reveals extracellular matrix regulates epidermal growth and function as epidermal stem cell niche
Spatial proteins expression is critical to identify exactly protein localization and function in tissues. By combining decellularization, laser-capture microdissection, and mass spectrometry, six different partitioned proteins among skin layers of stratum corneum (SC), granular-spinous (GS), basal l...
ORGANISM(S): Homo Sapiens 
2021-07-05 | PXD027093 |
ProteomicsTime-resolved extracellular matrix atlas of the developing human skin dermis
Skin aging is a physiological problem that remains a concern. Studies have demonstrated that the dermal extracellular matrix (ECM) plays important roles in skin aging; however, changes in ECM characteristics and molecules that are secreted to the extracellular space and involved in the formation of ...
ORGANISM(S): Homo Sapiens 
2022-11-28 | PXD016440 |
ProteomicsApplication of an iPSC-derived Organoid Model for Located Scleroderma Therapy
Scleroderma is a chronic connective tissue disease characterized by skin thickening and plaque morphea, as well as hard, shiny skin. Serious involvement is observed from the superficial dermis down to the fascia and muscle. However, this condition is difficult to treat and evaluate. In this study, i...
ORGANISM(S): Mus Musculus 
PXD025613 |
ProteomicsProteomics Characterization of COVID-19 lung tissues
The COVID-19 pandemic has emerged as a global health emergency due to its association with severe pneumonia and relative high mortality. However, the molecular characteristics and pathological features underlying COVID-19 pneumonia remain largely unknown. To characterize molecular mechanisms underly...
ORGANISM(S): Homo Sapiens 
2020-03-19 | PXD018094 |
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