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TranscriptomicsMicroarray skeletal muscle miR-499 overexpressing mice
This experiment was conducted to identify target genes of the microRNA-499 in skeletal muscle of transgenic mice that overexpressed miR-499. The following abstract from the submitted manuscript describes the major findings of this work. Coupling of mitochondrial function and skeletal muscle f...
ORGANISM(S): Mus musculus 
2016-09-03 | E-GEOD-72581 | biostudies-arrayexpress
UnknownTMT-based quantitative proteomic analysis reveals eggshell matrix protein changes correlated with eggshell quality in Jing Tint 6 laying hens of different ages.
Not available
S-EPMC10840124 | biostudies-literature
ProteomicsABPP-LC/MS results of covalent inhibitor targeting LC3A/B in HeLa cells
The autophagic ubiquitin-like protein LC3 functions through interactions with LC3-interaction regions (LIRs) of other autophagy proteins including autophagy receptors, which stands out as a promising protein-protein interaction (PPI) target for the intervention of autophagy. Through screening covale...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD026874 | Pride
Abpp Lc3 Autophagy Covalent 
ProteomicsA novel USP9X substrate TTK contributes to tumorigenesis in non-small cell lung cancer
The X-linked deubiquitinase, USP9X, is implicated in multiple cancers by targeting various substrates. Increased expression of USP9X is observed in non-small cell lung cancer (NSCLC) and is correlated with poor prognosis. However, the molecular mechanism for USP9X regulating tumor cell survival and ...
ORGANISM(S): Homo sapiens (Human) 
2018-05-07 | PXD007726 | Pride
Non-small cell lung cancer (nsclc)  quantitative proteomics  deubiquitinase  usp9x  ttk 
ProteomicsTMT-labeled mass spectrometry-based proteomics analysis in NCI-H1581 lung cancer cells upon AZD4547 treatment
FGFR1-amplified lung cancer cell line NCI-H1581 was treated with FGFR inhibitor AZD4547 (0.1μM) or DMSO vehicle for 24 hours. Then TMT-labeled mass spectrometry-based proteomics was carried out in cell lysates to analyze the differentially expressed proteins between two groups.
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD032227 | Pride
Tmt-labeled mass spectrometry Azd4547 Nci-h1581 
ProteomicsEnhancing Membrane Protein Identification Using a Simplified, Centrifugation and Detergent-based Membrane Extraction Approach
Membrane proteins may act as transporters, receptors, enzymes and adhesion-anchors, accounting for nearly 70% of pharmaceutical drug targets. Difficulties in efficient enrichment, extraction and solubilization still exist because of their relatively low abundance and poor solubility. A simplified me...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2018-01-31 | PXD008456 | Pride
Sequence coverage Identification Mass spectrometry Enrichment Membrane proteins 
ProteomicsEnhancing Membrane Protein Identification Using a Simplified, Centrifugation and Detergent-based Membrane Extraction Approach
Membrane proteins may act as transporters, receptors, enzymes and adhesion-anchors, accounting for nearly 70% of pharmaceutical drug targets. Difficulties in efficient enrichment, extraction and solubilization still exist because of their relatively low abundance and poor solubility. A simplified me...
ORGANISM(S): Mus musculus (Mouse) 
2019-09-27 | PXD007731 | Pride
Sequence coverage Identification Mass spectrometry Enrichment Membrane proteins 
UnknownAssisted reproductive techniques with congenital hypogonadotropic hypogonadism patients: a systematic review and meta-analysis.
Not available
S-EPMC6245556 | biostudies-literature
ProteomicsSILAC-based quantitative proteomic analysis of the livers of spontaneous obese and diabetic rhesus monkeys
Type 2 diabetes mellitus (TM) is a severely metabolic disorder that affects above 10% worldwide population. Obesity is a major cause of insulin resistance and contributes to the development of TM. Liver is an essential metabolic organ that plays crucial roles in the pathogenesis of obesity and diabe...
ORGANISM(S): Macaca mulatta (Rhesus macaque) 
2019-08-26 | PXD008825 | Pride
Spontaneous type 2 diabetes  liver  rhesus monkey  silac-based quantitative proteomics. 
TranscriptomicsTranscriptome profiling data for secondary vascular tissue regeneration in Populus tomentosa
Regeneration is a common strategy for plants to repair their damaged body plans after attack from other organisms or physical assaults. Trees with bark girdling on a large scale will grow new bark within one month and this bark regeneration after girdling system has been proven to be an efficient me...
ORGANISM(S): Populus tomentosa 
2012-07-25 | E-GEOD-25309 | biostudies-arrayexpress
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