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MetabolomicsCell Membrane Remodeling Mediates Polymyxin B Resistance in Klebsiella pneumoniae: An Integrated Proteomics and Metabolomics Study
Polymyxin B (PB) is introduced into the clinic as the last-line therapy against carbapenem-resistant Klebsiella pneumoniae (CRKP). Unfortunately, increased resistance to PB in Klebsiella pneumoniae (K. pneumoniae) has threatened global health. Resistance of K. pneumoniae ...
2022-03-04 | MTBLS4132 | MetaboLights
ProteomicsThe catalytic mechanism of vitamin K epoxide reduction in a cellular environment
Vitamin K epoxide reductases (VKOR) constitute a major family of integral membrane thiol oxidoreductases. In humans, VKOR sustains blood coagulation and bone mineralization through the vitamin K cycle. Previous chemical models assumed that the catalysis of human VKOR (hVKOR) starts from a fully redu...
ORGANISM(S): Homo sapiens (Human) 
2020-12-03 | PXD020676 | Pride
Human vkor Lc/ms/ms Catalytic mechanism 
ProteomicsiTRAQ-based proteomic analysis reveals genome-wide protein expression patterns in allohexaploid bread wheat in adaptation to potassium deficiency and an important role of jasmonic acid
Two-week old bread wheat seedlings hydroponically grown Hoagland solution were transferred to potassium (K+)-free conditions for 8 d, their root and leaf proteome profiles were assessed using iTRAQ proteome method, and NCBInr database combined with the recently published bread wheat genome informati...
ORGANISM(S): Triticum aestivum (Wheat) 
2017-10-09 | PXD003570 | Pride
Jasmonic acid Triticum aestivum l. Itraq Potassium deficiency 
TranscriptomicsMouse lung tumor tissue: Dnmt3a KO vs. Dnmt3a WT
Transcriptional profiling of mouse lung tumors comparing Dnmt3a KO/K-ras G12D mutant with Dnmt3a WT/K-ras G12D mutant. The goal is to search for the difference of mRNA abundance between Dnmt3a KO and WT tumors. Two-condition experiment, KO vs. WT tissure. Biological replicates: 12.
ORGANISM(S): Mus musculus 
2011-10-25 | E-GEOD-32415 | biostudies-arrayexpress
UnknownPotassium nickel(II) gallium phosphate hydrate, K[NiGa(2)(PO(4))(3)(H(2)O)(2)].
Not available
S-EPMC2977543 | biostudies-literature
ProteomicsMass spectrometry of co-immunoprecipitation using tobacco Maturase K as bait
Chloroplast group IIA introns derive from bacterial ribozymes. Their splicing likely requires Maturase K (MatK), which has been largely inaccessible to functional analyses being itself a chloroplast intron-encoded protein. Here we used co-immunoprecipitation coupled with proteomics to identify prote...
ORGANISM(S): Nicotiana tabacum (Common tobacco) 
2026-02-10 | PXD060055 | Pride
Lc-ms/ms Tobacco Co-immunoprecipitation Seedilings Chloroplasts 
UnknownCharacteristics and molecular basis of celecoxib modulation on K(v)7 potassium channels.
Not available
S-EPMC3230818 | biostudies-literature
UnknownAT2R (Angiotensin II Type 2 Receptor)-Mediated Regulation of NCC (Na-Cl Cotransporter) and Renal K Excretion Depends on the K Channel, Kir4.1.
Not available
S-EPMC5843543 | biostudies-literature
UnknownGene sequence analysis model construction based on k-mer statistics.
Not available
S-EPMC11392344 | biostudies-literature
TranscriptomicsKnockout mice reveal key roles for claudin-18 in alveolar fluid homeostasis.
Claudin proteins are major constituents of epithelial and endothelial tight junctions (TJ), where they serve as regulators of paracellular permeability to ions and solutes. Claudin-18, a member of the large claudin family, is highly expressed in lung epithelium. To elucidate the role of claudin-18 i...
ORGANISM(S): Mus musculus 
2014-04-06 | E-GEOD-48443 | biostudies-arrayexpress
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