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TranscriptomicsRNAseq of epidermis reconstructed from TSG-6-/- and TSG-6+/+ immortalized N/TERT keratinocytes and stimulated or not with interleukins 4 and 13 for 48h
TNFα-stimulated gene 6 (TSG-6) is an anti-inflammatory protein. In human epidermis, TSG-6 is secreted in extracellular matrix where it interacts with hyaluronan (HA). However, their functions are not well understood. In this study, immortalized N/TERT keratinocytes were edited by CRISPR/Cas9, used t...
ORGANISM(S): Homo sapiens 
2021-12-30 | E-MTAB-10095 | biostudies-arrayexpress
MetabolomicsTwo apples a day modulate human:microbiome co-metabolic processing of polyphenols, tyrosine and tryptophan

PURPOSE: Validated biomarkers of food intake (BFIs) have recently been suggested as a useful tool to assess adherence to dietary guidelines or compliance in human dietary interventions. Although many new candidate biomarkers have emerged in the last decades for different foods fr...

2020-04-28 | MTBLS469 | MetaboLights
ProteomicsAging induces hepatic oxidative stress and nuclear proteomic remodelling in liver from Wistar ratAging induces hepatic oxidative stress and nuclear proteomic remodelling in liver from Wistar rats
Aging induces oxidative stress and proteome remodeling in the nucleus from liver in Wistar rats
ORGANISM(S): Rattus norvegicus (Rat) 
2022-02-17 | PXD027773 | Pride
Oxidative stress nuclear liver wistar rat lc-ms/ms 
ProteomicsIgA transcytosis and tumor antigen recognition govern anti-tumor immunity in ovarian cancer
Although most ovarian cancers show prognostically relevant activated T-cell infiltrates, response rates to immune checkpoint inhibitors are very modest4. Memory B-cell and plasma cell infiltrates have been associated with better outcome in ovarian cancer, but the nature and functional relevance of t...
ORGANISM(S): Homo sapiens (Human) 
2020-12-01 | PXD018079 | Pride
Ovarian cancer Prm Immunoglobulin a Transcytosis Lc-ms/ms Immunotherapy 
ProteomicsDimeric IgA specifically disables intracellular mutated oncodrivers
Despite their long half-life, therapeutic antibodies are considered ineffective against intracellular antigens due to their perceived inability to penetrate epithelial cells. Using recombinant antibodies targeting common mutations in oncogenes, we show that dimeric IgA, but not the same antibody on ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD042914 | Pride
Transcytosis Cancer Therapeutic antibodies Immunoglobulin a 
MetabolomicsDiagnostic utility of clinicodemographic, biochemical and metabolite variables to identify viable pregnancies in a symptomatic cohort during early gestation.

Study question: Can a novel machine learning pipeline create predictive models that identify a composite biomarker to differentiate live normally sited pregnancies (LNSP) from non-viable pregnancies in women presenting with pain and/or bleeding in early gestation?

Summary answer: Serum met...

2025-08-14 | MTBLS6219 | MetaboLights
MetabolomicsLongitudinal multi-omics reveals subset-specific mechanisms underlying irritable bowel syndrome

The gut microbiome has been implicated in multiple human chronic gastrointestinal (GI) disorders. Determining its mechanistic role in disease has been difficult due to apparent disconnects between animal and human studies and lack of an integrated multi-omics view of disease-specific physiologica...

2020-09-08 | MTBLS1396 | MetaboLights
UnknownPrevention of incisional hernia after midline laparotomy with prophylactic mesh reinforcement: a meta-analysis and trial sequential analysis.
Not available
S-EPMC7260413 | biostudies-literature
ProteomicsSARS-CoV-2 protein encoded by ORF8 contains a histone mimic, disrupts chromatin regulation, and enhances replication
SARS-CoV-2 emerged in China at the end of 2019 and caused the global pandemic of COVID-19, a disease with high morbidity and mortality. While our understanding of this new virus is rapidly increasing, gaps remain in our understanding of how SARS-CoV-2 can effectively suppress host cell antiviral res...
ORGANISM(S): Homo sapiens (Human) 
2022-07-22 | PXD034379 | Pride
Epigenetics Infectious disease Sars-cov-2 
UnknownQuality of Life During Treatment With Chemohormonal Therapy: Analysis of E3805 Chemohormonal Androgen Ablation Randomized Trial in Prostate Cancer.
Not available
S-EPMC5891128 | biostudies-literature
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