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ProteomicsSOX4 AND SMARCA4 COOPERATIVELY REGULATE PI3K SIGNALING THROUGH TRANSCRIPTIONAL ACTIVATION OF TGFBR2 IN BASAL LIKE BREAST CANCER
Dysregulation of PI3K/Akt signaling is a dominant feature in basal-like or triple-negative breast cancers (TNBC). However, the mechanisms regulating this pathway are largely unknown in this subset of aggressive tumors. Here we demonstrate that the transcription factor SOX4 is a key regulator of PI3K...
ORGANISM(S): Homo sapiens (Human) 
2021-03-02 | PXD022811 | Pride
Breast cancer Smarca4 Transcription Epigenetics Tgfbr2 Swi/snf Pi3 kinase Sox4 Chromatin 
TranscriptomicsGenetic Heterogeneity in Mouse Mammary Tumors
Human cancers result from a complex series of genetic alterations resulting in heterogeneous disease states. Dissecting this heterogeneity is critical for understanding underlying mechanisms and providing opportunities for therapeutics matching the complexity. Mouse models of cancer have generally b...
ORGANISM(S): Mus musculus 
2010-03-03 | E-GEOD-15904 | biostudies-arrayexpress
UnknownRole of TGF-β receptor III localization in polarity and breast cancer progression.
Not available
S-EPMC4116303 | biostudies-literature
UnknownEctodomain shedding of TβRIII is required for TβRIII-mediated suppression of TGF-β signaling and breast cancer migration and invasion.
Not available
S-EPMC4142606 | biostudies-literature
UnknownMulti-Omic Data Interpretation to Repurpose Subtype Specific Drug Candidates for Breast Cancer.
Not available
S-EPMC6514249 | biostudies-literature
UnknownAnchorage-independent cell growth signature identifies tumors with metastatic potential.
Not available
S-EPMC3008357 | biostudies-literature
ProteomicsSOX4 AND SMARCA4 COOPERATIVELY REGULATE PI3K SIGNALING THROUGH TRANSCRIPTIONAL ACTIVATION OF TGFBR2 IN TRIPLE NEGATIVE BREAST CANCER
Dysregulation of PI3K/Akt signaling is a dominant feature in basal-like or triple-negative breast cancers (TNBC). However, the mechanisms regulating this pathway are largely unknown in this subset of aggressive tumors. Here we demonstrate that the transcription factor SOX4 is a key regulator of PI3K...
ORGANISM(S): Homo sapiens (Human) 
2021-03-03 | PXD022596 | Pride
Breast cancer Smarca4 Transcription Epigenetics Tgfbr2 Swi/snf Pi3 kinase Sox4 Chromatin 
TranscriptomicsGene expression profiles of Ras mutants.
Gene expression profiles were collected from HEK-HT cells expressing H-Ras with Ras-activating (G12V), Raf-activating (G12V,T35S), RalGEF-activating (G12V,E37G), or PI3K-activating (G12V,Y40C) mutations. Keywords: Comparison of Ras pathway components. THX=control; 12V=G12V mutation; 35S=G12V,T35S m...
ORGANISM(S): Homo sapiens 
2009-02-21 | E-GEOD-14934 | biostudies-arrayexpress
UnknownVorinostat plus tacrolimus/methotrexate to prevent GVHD after myeloablative conditioning, unrelated donor HCT.
Not available
S-EPMC5639486 | biostudies-literature
UnknownA genomic strategy to elucidate modules of oncogenic pathway signaling networks.
Not available
S-EPMC2694616 | biostudies-literature
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